Effect of Genetic-Environmental Interaction on Chinese Childhood Myopia

Overview

Journal J Ophthalmol

Publisher Wiley

Specialty Ophthalmology

Date 2020 Nov 23

PMID 33224523

Citations 17

Authors

Xiyan Zhang

Yan Wang

Chenwei Pan

Wenyi Yang

Yao Xiang

Jie Yang

Fengyun Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: The purpose of this study was to evaluate the effect of genetic-environmental interaction on myopia in Chinese children aged 6 to 9 years.

Methods: Students had the physical examination and were required to provide basic demographic information. Their families were asked to fill in a questionnaire concerning factors related to myopia. Multiple regression analysis was performed, and adjusted risk ratio values were calculated to assess the role between gene and environment. Value of the environmental and genetic index (EGI) was calculated to demonstrate the effect of genetic-environmental interaction on myopia.

Results: The prevalence of myopia maintained at a high level. EGI was calculated as 0.125 suggesting that genetic factors may play the 12.5% role in the formation of myopia and environmental factors may play a role of 87.5% in the formation of myopia.

Conclusions: For young pupils aged 6 to 9 years, myopia prevalence maintained at a high level, and duration of homework time and staring at electronic screen were the strongest factors associated with myopia. The calculated value of EGI was low, which suggests that environmental factors may play the leading role in the formation of myopia. A long-term follow-up research to improve the accuracy value of EGI is our next job.

Citing Articles

Effects of Insufficient Sleep on Myopia in Children: A Systematic Review and Meta-Analysis.

Zhao X, He Y, Zhang J, Lin S, Zou H, Ma Y Nat Sci Sleep. 2024; 16:1387-1406.

PMID: 39308665 PMC: 11416795. DOI: 10.2147/NSS.S472748.

Establishing and Validating Refractive Error Reference Values for Myopia Prediction Among Children Aged 6-12 Years - Jiangsu Province, China, 2018-2023.

Zhang X, Pan C, Du W, Zhou Y, Yang J, Wang Y China CDC Wkly. 2024; 6(32):804-810.

PMID: 39157047 PMC: 11325093. DOI: 10.46234/ccdcw2024.175.

Regional disparities in the prevalence and correlated factors of myopia in children and adolescents in Gansu, China.

Wang J, Li S, He S, Feng Y, Li P Front Med (Lausanne). 2024; 11:1375080.

PMID: 39149607 PMC: 11324564. DOI: 10.3389/fmed.2024.1375080.

The Impact of Sunshine Duration on Myopia in Central China: Insights from Populational and Spatial Analysis in Hubei.

Ma R, Zhou L, Li W, Li Y, Hu D, Lu Y Int J Gen Med. 2024; 17:2129-2142.

PMID: 38766596 PMC: 11102173. DOI: 10.2147/IJGM.S462734.

Crosstalk between heredity and environment in myopia: An overview.

Hao J, Yang Z, Zhang R, Ma Z, Liu J, Bi H Heliyon. 2024; 10(8):e29715.

PMID: 38660258 PMC: 11040123. DOI: 10.1016/j.heliyon.2024.e29715.

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