Assessment of the Relationship Between Endocan and Obstructive Sleep Apnea Severity

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2020 Nov 23

PMID 33224333

Citations 3

Authors

Hamdi Pusuroglu

Umut Somuncu

Ismail Bolat

Ozgur Akgul

Hayriye Ak Yildirim

Sinem Ozbay Ozyilmaz

Vesile Ornek

Ozgur Surgit

Huseyin Karakurt

Ayfer Utkusavas

Nermina Alagic

Aydin Yildirim

Affiliations

Soon will be listed here.

Abstract

Introduction: Obstructive sleep apnea (OSA) and endothelial dysfunction are associated with cardiovascular risk factors and the development of atherosclerosis. Endocan is a marker of endothelial dysfunction, while obstructive sleep apnea is one of the causes of endothelial dysfunction. In this study, we investigated the relationship between endocan and obstructive sleep apnea severity.

Material And Methods: A total of 179 patients with snoring complaints were included. All patients underwent polysomnography, and based on the results, the participations were allocated to the control group ( = 39) or to the obstructive sleep apnea group ( = 140). The OSA group was classified as having mild (apnea-hypopnea index (AHI) = 5-15; = 43), moderate (AHI = 15-30; = 42), or severe OSA (AHI > 30; = 55). All participations had their endocan levels measured.

Results: Endocan levels in OSA patients were significantly higher than in the control group (11.8 (3.13-200) vs 3.13 (3.13-23) ng/ml, < 0.001). Also, endocan levels were significantly higher in the severe OSA group than moderate and mild obstructive OSA (13.2 (3.13-200), 12.6 (3.13-200) and 8.44 (3.13-50.5) ng/ml, = 0.015, respectively). Multiple logistic regression analysis showed that smoking, age and endocan levels were independent predictors of OSA severity ( = 0.024, = 0.037, = 0.004, respectively).

Conclusions: Endocan seems to be a potential risk stratification marker in this patient population.

Citing Articles

High circulating endocan in chronic kidney disease? A systematic review and meta-analysis.

Khalaji A, Behnoush A, Kia Y, Alehossein P, Bahiraie P PLoS One. 2023; 18(8):e0289710.

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Continuous positive airway pressure may improve hypertension in patients with obstructive sleep apnea-hypopnea syndrome by inhibiting inflammation and oxidative stress.

Wang X, Guan L, Wu C, Zhao Y, Zhao G Arch Med Sci. 2023; 19(1):237-241.

PMID: 36817664 PMC: 9897073. DOI: 10.5114/aoms/156490.

Relationship Between Obstructive Sleep Apnea Severity and Serum Endocan Levels in Patients With Hypertension.

Yazan S, Karakurt H, Pusuroglu H Tex Heart Inst J. 2023; 50(1).

PMID: 36724451 PMC: 9969776. DOI: 10.14503/THIJ-21-7664.

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