Sedative and Analgesic Pharmacokinetics During Pediatric ECMO

Overview

Journal J Pediatr Pharmacol Ther

Specialty Pediatrics

Date 2020 Nov 20

PMID 33214778

Citations 3

Authors

Kanecia O Zimmerman

Samantha H Dallefeld

Christoph P Hornik

Kevin M Watt

Affiliations

Soon will be listed here.

Abstract

Sedatives and analgesics are often administered to critically ill children supported by extracorporeal membrane oxygenation (ECMO) to facilitate comfort and to decrease risks of life-threatening complications. Optimization of sedative and analgesic dosing is necessary to achieve desired therapeutic benefits and must consider interactions between the circuit and patient that may affect drug metabolism, clearance, and impact on target organs. This paper reviews existing and pediatric literature concerning the effects of the ECMO circuit on sedative and analgesic disposition and offers dosing guidance for the management of critically ill children receiving these drugs.

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