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Multicellular Contractility Contributes to the Emergence of Mesothelioma Nodules

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Journal Sci Rep
Specialty Science
Date 2020 Nov 19
PMID 33208866
Citations 1
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Abstract

Malignant pleural mesothelioma (MPM) has an overall poor prognosis and unsatisfactory treatment options. MPM nodules, protruding into the pleural cavity may have growth and spreading dynamics distinct that of other solid tumors. We demonstrate that multicellular aggregates can develop spontaneously in the majority of tested MPM cell lines when cultured at high cell density. Surprisingly, the nodule-like aggregates do not arise by excessive local cell proliferation, but by myosin II-driven cell contractility. Prominent actin cables, spanning several cells, are abundant both in cultured aggregates and in MPM surgical specimens. We propose a computational model for in vitro MPM nodule development. Such a self-tensioned Maxwell fluid exhibits a pattern-forming instability that was studied by analytical tools and computer simulations. Altogether, our findings may underline a rational for targeting the actomyosin system in MPM.

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Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow.

Kovacs I, Bugyik E, Dezso K, Tarnoki-Zach J, Mehes E, Gulyas M Transl Lung Cancer Res. 2022; 11(6):991-1008.

PMID: 35832452 PMC: 9271443. DOI: 10.21037/tlcr-21-828.

References
1.
Mierke C, Bretz N, Altevogt P . Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion. J Biol Chem. 2011; 286(40):34858-71. PMC: 3186419. DOI: 10.1074/jbc.M111.245183. View

2.
Gandalovicova A, Rosel D, Fernandes M, Vesely P, Heneberg P, cermak V . Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges. Trends Cancer. 2017; 3(6):391-406. PMC: 5482322. DOI: 10.1016/j.trecan.2017.04.008. View

3.
Murray J, Oster G, Harris A . A mechanical model for mesenchymal morphogenesis. J Math Biol. 1983; 17(1):125-9. DOI: 10.1007/BF00276117. View

4.
Straight A, Cheung A, Limouze J, Chen I, Westwood N, Sellers J . Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science. 2003; 299(5613):1743-7. DOI: 10.1126/science.1081412. View

5.
Manoussaki D, Lubkin S, Vernon R, Murray J . A mechanical model for the formation of vascular networks in vitro. Acta Biotheor. 1996; 44(3-4):271-82. DOI: 10.1007/BF00046533. View