Marine Bioactive Compounds Against : Challenges and Future Prospects

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Nov 19

PMID 33207554

Citations 3

Authors

Chukwuemeka Samson Ahamefule

Blessing C Ezeuduji

James C Ogbonna

Anene N Moneke

Anthony C Ike

Bin Wang

Cheng Jin

Wenxia Fang

Affiliations

Soon will be listed here.

Abstract

With the mortality rate of invasive aspergillosis caused by reaching almost 100% among some groups of patients, and with the rapidly increasing resistance of to available antifungal drugs, new antifungal agents have never been more desirable than now. Numerous bioactive compounds were isolated and characterized from marine resources. However, only a few exhibited a potent activity against when compared to the multitude that did against some other pathogens. Here, we review the marine bioactive compounds that display a bioactivity against The challenges hampering the discovery of antifungal agents from this rich habitat are also critically analyzed. Further, we propose strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising in vivo antifungal agents with new modes of action.

Citing Articles

Juxtaposing Caenorhabditis elegans-Pathogenic Mould Model with Other Models; How Reliable Is This Nematode Model? A Mini Review.

Ahamefule C, Ahamefule B, Ike A, Ogbonna J, Moneke A Curr Microbiol. 2023; 80(4):105.

PMID: 36790616 DOI: 10.1007/s00284-023-03209-z.

A critical look at challenges and future scopes of bioactive compounds and their incorporations in the food, energy, and pharmaceutical sector.

Pai S, Hebbar A, Selvaraj S Environ Sci Pollut Res Int. 2022; 29(24):35518-35541.

PMID: 35233673 PMC: 9079019. DOI: 10.1007/s11356-022-19423-4.

as an Infection Model for Pathogenic Mold and Dimorphic Fungi: Applications and Challenges.

Ahamefule C, Ezeuduji B, Ogbonna J, Moneke A, Ike A, Jin C Front Cell Infect Microbiol. 2021; 11:751947.

PMID: 34722339 PMC: 8554291. DOI: 10.3389/fcimb.2021.751947.

References

Hagiwara D, Miura D, Shimizu K, Paul S, Ohba A, Gonoi T . A Novel Zn2-Cys6 Transcription Factor AtrR Plays a Key Role in an Azole Resistance Mechanism of Aspergillus fumigatus by Co-regulating cyp51A and cdr1B Expressions. PLoS Pathog. 2017; 13(1):e1006096. PMC: 5215518. DOI: 10.1371/journal.ppat.1006096. View

Morgenstern A, Paetz C, Behrend A, Spiteller D . Divalent transition-metal-ion stress induces prodigiosin biosynthesis in Streptomyces coelicolor M145: formation of coeligiosins. Chemistry. 2015; 21(16):6027-32. DOI: 10.1002/chem.201405733. View

Jimenez-Ortigosa C, Aimanianda V, Muszkieta L, Mouyna I, Alsteens D, Pire S . Chitin synthases with a myosin motor-like domain control the resistance of Aspergillus fumigatus to echinocandins. Antimicrob Agents Chemother. 2012; 56(12):6121-31. PMC: 3497188. DOI: 10.1128/AAC.00752-12. View

Mohapatra B, Bapuji M, Sree A . Antifungal efficacy of bacteria isolated from marine sedentary organisms. Folia Microbiol (Praha). 2002; 47(1):51-5. DOI: 10.1007/BF02818565. View

Perez-Victoria I, Oves-Costales D, Lacret R, Martin J, Sanchez-Hidalgo M, Diaz C . Structure elucidation and biosynthetic gene cluster analysis of caniferolides A-D, new bioactive 36-membered macrolides from the marine-derived Streptomyces caniferus CA-271066. Org Biomol Chem. 2019; 17(11):2954-2971. DOI: 10.1039/c8ob03115k. View

Lakshmi V, Srivastava S, Mishra S, Shukla P . Antifungal activity of bivittoside-D from Bohadschia vitiensis (Semper). Nat Prod Res. 2011; 26(10):913-8. DOI: 10.1080/14786419.2010.534096. View

Lacret R, Oves-Costales D, Gomez C, Diaz C, de la Cruz M, Perez-Victoria I . New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis. Mar Drugs. 2015; 13(1):128-40. PMC: 4306928. DOI: 10.3390/md13010128. View

Manoharan R, Lee J, Kim Y, Kim S, Lee J . Inhibitory effects of the essential oils α-longipinene and linalool on biofilm formation and hyphal growth of Candida albicans. Biofouling. 2017; 33(2):143-155. DOI: 10.1080/08927014.2017.1280731. View

Edrada R, Ebel R, Supriyono A, Wray V, Schupp P, Steube K . Swinhoeiamide A, a new highly active calyculin derivative from the marine sponge Theonella swinhoei. J Nat Prod. 2002; 65(8):1168-72. DOI: 10.1021/np020049d. View

10.

Lamoth F, Juvvadi P, Soderblom E, Moseley M, Asfaw Y, Steinbach W . Identification of a key lysine residue in heat shock protein 90 required for azole and echinocandin resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2014; 58(4):1889-96. PMC: 4023766. DOI: 10.1128/AAC.02286-13. View

11.

Han H, Yi Y, Li L, Liu B, La M, Zhang H . Antifungal active triterpene glycosides from sea cucumber Holothuria scabra. Yao Xue Xue Bao. 2009; 44(6):620-4. View

12.

Mickymaray S, Alturaiki W . Antifungal Efficacy of Marine Macroalgae against Fungal Isolates from Bronchial Asthmatic Cases. Molecules. 2018; 23(11). PMC: 6278659. DOI: 10.3390/molecules23113032. View

13.

Bora S, Kumar A, Mishra S, Satyarthee G, Singh P, Sawarkar D . Intracranial aspergillosis amongst immunocompetent patients: An experience with combined surgical and medical management of 18 patients. Clin Neurol Neurosurg. 2019; 186:105511. DOI: 10.1016/j.clineuro.2019.105511. View

14.

Austin B . The value of cultures to modern microbiology. Antonie Van Leeuwenhoek. 2017; 110(10):1247-1256. DOI: 10.1007/s10482-017-0840-8. View

15.

Kovalchuk V, Voronkina A, Binnewerg B, Schubert M, Muzychka L, Wysokowski M . Naturally Drug-Loaded Chitin: Isolation and Applications. Mar Drugs. 2019; 17(10). PMC: 6835269. DOI: 10.3390/md17100574. View

16.

Linder K, McDonald P, Kauffman C, Revankar S, Chandrasekar P, Miceli M . Invasive aspergillosis in patients following umbilical cord blood transplant. Bone Marrow Transplant. 2018; 54(2):308-311. DOI: 10.1038/s41409-018-0230-5. View

17.

Prigitano A, Esposto M, Biffi A, De Lorenzis G, Favuzzi V, Koncan R . Triazole resistance in Aspergillus fumigatus isolates from patients with cystic fibrosis in Italy. J Cyst Fibros. 2016; 16(1):64-69. DOI: 10.1016/j.jcf.2016.06.006. View

18.

Webb B, Vikram H . Chronic invasive sinus aspergillosis in immunocompetent hosts: a geographic comparison. Mycopathologia. 2010; 170(6):403-10. DOI: 10.1007/s11046-010-9338-x. View

19.

Peters T, Tillotson J, Yeomans A, Wilmore S, Lemm E, Jimenez-Romero C . Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with Antitumor Activity. Clin Cancer Res. 2018; 24(17):4256-4270. PMC: 6500731. DOI: 10.1158/1078-0432.CCR-17-3645. View

20.

Wang W, Park C, Oh E, Sung Y, Lee J, Park K . Benzophenone Compounds, from a Marine-Derived Strain of the Fungus , Inhibit Proliferation of Pancreatic Cancer Cells by Targeting the MEK/ERK Pathway. J Nat Prod. 2019; 82(12):3357-3365. DOI: 10.1021/acs.jnatprod.9b00646. View