Desmoplastic Fibroma of the Jaw Bones: A Series of Twenty-two Cases

Overview

Journal J Bone Oncol

Publisher Elsevier

Date 2020 Nov 18

PMID 33204607

Citations 7

Authors

Devrim Kahraman

Berkem Karakoyunlu

Ulker Karagece

Umit Ertas

Omer Gunhan

Affiliations

Soon will be listed here.

Abstract

Desmoplastic fibroma (DF) is an intraosseous counterpart of desmoid-type soft tissue fibromatosis. It is most frequently seen in the jawbones. The clinical and radiological features of the present cases were nonspecific. The accumulation of beta-catenin in the nuclei of neoplastic cells which is a diagnostic feature of desmoid-type soft tissue fibromatosis could not be detectED in the present DF series. The aim of this study is to report a series of 22 cases of DF involving either mandible or maxilla. A retrospective evaluation of desmoplastic fibroma and beta-catenin, smooth muscle actin, nestin, cyclin D1 immunostaining's patterns. Most of the DF cases expressed only cytoplasmic beta-catenin immunostainings. We suggest that nuclear beta-catenin staining may not be used as a corroborating the diagnosis of DF. Immunohistochemical staining difference of jaw bone desmoplastic fibromas from other soft tissue and bone lesions may be related to the origination of jaw bone from The neural crest. Strong nestin and cyclin D1 positivity in our series supported this. A combined clinical, radiological, and histopathological analysis of the DF cases is essential in the diagnosis and management.

Citing Articles

Exploring Head and Neck Fibromatosis: A Case Series and Literature Review.

Babu A, Singh S, Patel P, Lakhera K, Mehta D, Singhal P Indian J Surg Oncol. 2024; 15(4):849-856.

PMID: 39555333 PMC: 11564593. DOI: 10.1007/s13193-024-02010-z.

Massive Desmoplastic Fibroma of the Proximal Tibia: Case Report.

Pujol O, Castellanos S, Carrasco M, Garzon A, Romagosa C, Velez R Rev Bras Ortop (Sao Paulo). 2024; 59(Suppl 1):e114-e118.

PMID: 39027175 PMC: 11254431. DOI: 10.1055/s-0043-1771492.

A multicentric case study of fibroblastic and myofibroblastic oral spindle cell lesions.

Jot K, Nayyar V, Surya V, Mishra D, Sowmya S, Augustine D J Oral Maxillofac Pathol. 2024; 27(4):629-641.

PMID: 38304501 PMC: 10829460. DOI: 10.4103/jomfp.jomfp_282_23.

Low-Grade Myofibroblastic Sarcoma of the Oral and Maxillofacial Region: An International Clinicopathologic Study of 13 Cases and Literature Review.

Giraldo-Roldan D, Louredo B, Mendes Penafort P, Pontes H, Alves A, Lima F Head Neck Pathol. 2023; 17(3):832-850.

PMID: 37540486 PMC: 10513986. DOI: 10.1007/s12105-023-01577-3.

Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions.

Hassaf-Arreola A, Caro-Sanchez C, Dominguez-Malagon H, Irigoyen-Camacho M, Almeida O, Sanchez-Romero C Med Oral Patol Oral Cir Bucal. 2022; 27(6):e497-e506.

PMID: 36243994 PMC: 9648641. DOI: 10.4317/medoral.25326.

References

Saito T, Oda Y, Kawaguchi K, Tanaka K, Matsuda S, Tamiya S . Possible association between higher beta-catenin mRNA expression and mutated beta-catenin in sporadic desmoid tumors: real-time semiquantitative assay by TaqMan polymerase chain reaction. Lab Invest. 2002; 82(1):97-103. DOI: 10.1038/labinvest.3780399. View

Xu L, Cui W, Zhou W, Li D, Li L, Zhao P . Activation of Wnt/β-catenin signalling is required for TGF-β/Smad2/3 signalling during myofibroblast proliferation. J Cell Mol Med. 2017; 21(8):1545-1554. PMC: 5542906. DOI: 10.1111/jcmm.13085. View

GRIFFITH J, IRBY W . DESMOPLASTIC FIBROMA. REPORT OF A RARE TUMOR OF THE ORAL STRUCTURES. Oral Surg Oral Med Oral Pathol. 1965; 20:269-75. DOI: 10.1016/0030-4220(65)90201-x. View

Tejpar S, Nollet F, Li C, Wunder J, Michils G, Dal Cin P . Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor). Oncogene. 1999; 18(47):6615-20. DOI: 10.1038/sj.onc.1203041. View

Saito T, Oda Y, Tanaka K, Matsuda S, Tamiya S, Iwamoto Y . beta-catenin nuclear expression correlates with cyclin D1 overexpression in sporadic desmoid tumours. J Pathol. 2001; 195(2):222-8. DOI: 10.1002/path.942. View

Hauben E, Jundt G, Cleton-Jansen A, Yavas A, Kroon H, Van Marck E . Desmoplastic fibroma of bone: an immunohistochemical study including beta-catenin expression and mutational analysis for beta-catenin. Hum Pathol. 2005; 36(9):1025-30. DOI: 10.1016/j.humpath.2005.07.004. View

Mirando A, Maruyama T, Fu J, Yu H, Hsu W . β-catenin/cyclin D1 mediated development of suture mesenchyme in calvarial morphogenesis. BMC Dev Biol. 2010; 10:116. PMC: 3001432. DOI: 10.1186/1471-213X-10-116. View

Seper L, Burger H, Vormoor J, Joos U, Kleinheinz J . Agressive fibromatosis involving the mandible--case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004; 99(1):30-8. DOI: 10.1016/j.tripleo.2004.03.026. View

Azola A, Wartmann C, Fischer M, Ambro B, Pereira K . Desmoplastic fibroma arising from the anterior maxillary sinus in a child. Arch Otolaryngol Head Neck Surg. 2012; 138(9):859-62. DOI: 10.1001/archoto.2012.1661. View

10.

Said-Al-Naief N, Fernandes R, Louis P, Bell W, Siegal G . Desmoplastic fibroma of the jaw: a case report and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005; 101(1):82-94. DOI: 10.1016/j.tripleo.2005.03.034. View

11.

Ikeshima A, Utsunomiya T . Case report of intra-osseous fibroma: a study on odontogenic and desmoplastic fibromas with a review of the literature. J Oral Sci. 2005; 47(3):149-57. DOI: 10.2334/josnusd.47.149. View

12.

Lloyd B, Tee B, Headley C, Emam H, Mallery S, Sun Z . Similarities and differences between porcine mandibular and limb bone marrow mesenchymal stem cells. Arch Oral Biol. 2017; 77:1-11. PMC: 5366281. DOI: 10.1016/j.archoralbio.2017.01.012. View

13.

Graf D, Malik Z, Hayano S, Mishina Y . Common mechanisms in development and disease: BMP signaling in craniofacial development. Cytokine Growth Factor Rev. 2016; 27:129-39. PMC: 4753105. DOI: 10.1016/j.cytogfr.2015.11.004. View

14.

Sellin J, Umar S, Xiao J, Morris A . Increased beta-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo. Cancer Res. 2001; 61(7):2899-906. View

15.

Isern J, Garcia-Garcia A, Martin A, Arranz L, Martin-Perez D, Torroja C . The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function. Elife. 2014; 3:e03696. PMC: 4381911. DOI: 10.7554/eLife.03696. View

16.

Okubo T, Saito T, Takagi T, Suehara Y, Kaneko K . Desmoplastic fibroma of the rib with cystic change: a case report and literature review. Skeletal Radiol. 2013; 43(5):703-8. DOI: 10.1007/s00256-013-1772-7. View

17.

Khatib B, Pogrel M . Desmoplastic fibroma of the mandible in young children-a case series. Int J Oral Maxillofac Surg. 2016; 46(2):173-180. DOI: 10.1016/j.ijom.2016.09.018. View

18.

Min R, Zun Z, Lizheng W, Minjun D, Shengwen L, Wenjun Y . Oral and maxillofacial desmoid-type fibromatoses in an eastern Chinese population: a report of 20 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 111(3):340-5. DOI: 10.1016/j.tripleo.2010.10.019. View

19.

Onishi S, Baba Y, Yokoi F, Ide K, Ohyama M, Nishifuji K . Progenitor cells expressing nestin, a neural crest stem cell marker, differentiate into outer root sheath keratinocytes. Vet Dermatol. 2019; 30(5):365-e107. DOI: 10.1111/vde.12771. View

20.

Inwards C, Unni K, Beabout J, Sim F . Desmoplastic fibroma of bone. Cancer. 1991; 68(9):1978-83. DOI: 10.1002/1097-0142(19911101)68:9<1978::aid-cncr2820680922>3.0.co;2-h. View