Emerging Roles of Liver Sinusoidal Endothelial Cells in Nonalcoholic Steatohepatitis

Overview

Journal Biology (Basel)

Publisher MDPI

Specialty Biology

Date 2020 Nov 17

PMID 33198153

Citations 22

Authors

Kunimaro Furuta

Qianqian Guo

Petra Hirsova

Samar H Ibrahim

Affiliations

Soon will be listed here.

Abstract

Nonalcoholic steatohepatitis (NASH) has become a growing public health problem worldwide, yet its pathophysiology remains unclear. Liver sinusoidal endothelial cells (LSEC) have unique morphology and function, and play a critical role in liver homeostasis. Emerging literature implicates LSEC in many pathological processes in the liver, including metabolic dysregulation, inflammation, angiogenesis, and carcinogenesis. In this review, we highlight the current knowledge of the role of LSEC in each of the progressive phases of NASH pathophysiology (steatosis, inflammation, fibrosis, and the development of hepatocellular carcinoma). We discuss processes that have important roles in NASH progression including the detrimental transformation of LSEC called "capillarization", production of inflammatory and profibrogenic mediators by LSEC as well as LSEC-mediated angiogenesis. The current review has a special emphasis on LSEC adhesion molecules, and their key role in the inflammatory response in NASH. Moreover, we discuss the pathogenic role of extracellular vesicles and their bioactive cargos in liver intercellular communication, inflammation, and fibrosis. Finally, we highlight LSEC-adhesion molecules and derived bioactive product as potential therapeutic targets for human NASH.

Citing Articles

Sinusoidal communication in chronic liver disease.

Gibert-Ramos A, Andres-Rozas M, Pasto R, Alfaro-Retamero P, Guixe-Muntet S, Gracia-Sancho J Clin Mol Hepatol. 2024; 31(1):32-55.

PMID: 39355871 PMC: 11791556. DOI: 10.3350/cmh.2024.0734.

Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis.

Eberhard D, Balkenhol S, Koster A, Follert P, Upschulte E, Ostermann P Nat Cardiovasc Res. 2024; 3(6):734-753.

PMID: 39196233 PMC: 11358038. DOI: 10.1038/s44161-024-00487-z.

Key factor screening in mouse NASH model using single-cell sequencing combined with machine learning.

Song Y, Ge J, Ding M, Zheng Y Heliyon. 2024; 10(13):e33597.

PMID: 39040415 PMC: 11260934. DOI: 10.1016/j.heliyon.2024.e33597.

Glycogen synthase kinase 3 activity enhances liver inflammation in MASH.

Khoury M, Guo Q, Furuta K, Correia C, Meroueh C, Kim Lee H JHEP Rep. 2024; 6(6):101073.

PMID: 38882600 PMC: 11179260. DOI: 10.1016/j.jhepr.2024.101073.

Single-cell transcriptome reveals a novel mechanism of C-Kit-liver sinusoidal endothelial cells in NASH.

Li H, Gao Y, Wu J, Li J, Fu S, Xu M Cell Biosci. 2024; 14(1):31.

PMID: 38461242 PMC: 10925010. DOI: 10.1186/s13578-024-01215-7.

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