Serology in a Clinical Population With Persistent Symptoms and Suspected Tick-Borne Illness

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2020 Nov 16

PMID 33195313

Citations 3

Authors

Shannon L Delaney

Lilly A Murray

Claire E Aasen

Clair E Bennett

Ellen Brown

Brian A Fallon

Affiliations

Soon will be listed here.

Abstract

Eighty-two patients seeking consultation for long-term sequalae after suspected tick-borne illness were consecutively tested for antibodies using a recombinant glycerophosphodiester phosphodiesterase (GlpQ) enzyme immunoassay. Twenty-one of the 82 patients (26%) tested positive on the GlpQ IgG ELISA. Nearly all of the patients (98%) had no prior testing, indicating that clinicians rarely test for this emerging tick-borne pathogen. Compared to patients who solely tested positive for Lyme disease antibodies, patients with antibodies presented with significantly more sleepiness and pain. A prospective study is needed to ascertain the relationship between the presence of antibodies and persistent symptoms.

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