Green Synthesis of Metallic Nanoparticles and Their Potential Applications to Treat Cancer

Overview

Journal Front Chem

Specialty Chemistry

Date 2020 Nov 16

PMID 33195027

Citations 79

Authors

Dan Zhang

Xin-Lei Ma

Yan Gu

He Huang

Guang-Wei Zhang

Affiliations

Soon will be listed here.

Abstract

Nanoparticle synthesis using microorganisms and plants by green synthesis technology is biologically safe, cost-effective, and environment-friendly. Plants and microorganisms have established the power to devour and accumulate inorganic metal ions from their neighboring niche. The biological entities are known to synthesize nanoparticles both extra and intracellularly. The capability of a living system to utilize its intrinsic organic chemistry processes in remodeling inorganic metal ions into nanoparticles has opened up an undiscovered area of biochemical analysis. Nanotechnology in conjunction with biology gives rise to an advanced area of nanobiotechnology that involves living entities of both prokaryotic and eukaryotic origin, such as algae, cyanobacteria, actinomycetes, bacteria, viruses, yeasts, fungi, and plants. Every biological system varies in its capabilities to supply metallic nanoparticles. However, not all biological organisms can produce nanoparticles due to their enzymatic activities and intrinsic metabolic processes. Therefore, biological entities or their extracts are used for the green synthesis of metallic nanoparticles through bio-reduction of metallic particles leading to the synthesis of nanoparticles. These biosynthesized metallic nanoparticles have a range of unlimited pharmaceutical applications including delivery of drugs or genes, detection of pathogens or proteins, and tissue engineering. The effective delivery of drugs and tissue engineering through the use of nanotechnology exhibited vital contributions in translational research related to the pharmaceutical products and their applications. Collectively, this review covers the green synthesis of nanoparticles by using various biological systems as well as their applications.

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References

Kobayashi M, Tomita S, Sawada K, Shiba K, Yanagi H, Yamashita I . Chiral meta-molecules consisting of gold nanoparticles and genetically engineered tobacco mosaic virus. Opt Express. 2012; 20(22):24856-63. DOI: 10.1364/OE.20.024856. View

Love A, Makarov V, Yaminsky I, Kalinina N, Taliansky M . The use of tobacco mosaic virus and cowpea mosaic virus for the production of novel metal nanomaterials. Virology. 2014; 449:133-9. DOI: 10.1016/j.virol.2013.11.002. View

Shankar S, Rai A, Ahmad A, Sastry M . Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth. J Colloid Interface Sci. 2004; 275(2):496-502. DOI: 10.1016/j.jcis.2004.03.003. View

Pollmann K, Raff J, Merroun M, Fahmy K, Selenska-Pobell S . Metal binding by bacteria from uranium mining waste piles and its technological applications. Biotechnol Adv. 2005; 24(1):58-68. DOI: 10.1016/j.biotechadv.2005.06.002. View

Wang L, Chen X, Zhan J, Chai Y, Yang C, Xu L . Synthesis of gold nano- and microplates in hexagonal liquid crystals. J Phys Chem B. 2006; 109(8):3189-94. DOI: 10.1021/jp0449152. View

Johnston C, Wyatt M, Li X, Ibrahim A, Shuster J, Southam G . Gold biomineralization by a metallophore from a gold-associated microbe. Nat Chem Biol. 2013; 9(4):241-3. DOI: 10.1038/nchembio.1179. View

Castro L, Blazquez M, Munoz J, Gonzalez F, Ballester A . Biological synthesis of metallic nanoparticles using algae. IET Nanobiotechnol. 2013; 7(3):109-16. DOI: 10.1049/iet-nbt.2012.0041. View

Parikh R, Singh S, Prasad B, Patole M, Sastry M, Shouche Y . Extracellular synthesis of crystalline silver nanoparticles and molecular evidence of silver resistance from Morganella sp.: towards understanding biochemical synthesis mechanism. Chembiochem. 2008; 9(9):1415-22. DOI: 10.1002/cbic.200700592. View

Lengke M, Fleet M, Southam G . Biosynthesis of silver nanoparticles by filamentous cyanobacteria from a silver(I) nitrate complex. Langmuir. 2007; 23(5):2694-9. DOI: 10.1021/la0613124. View

10.

Iravani S, Zolfaghari B . Green synthesis of silver nanoparticles using Pinus eldarica bark extract. Biomed Res Int. 2013; 2013:639725. PMC: 3780616. DOI: 10.1155/2013/639725. View

11.

Hulkoti N, Taranath T . Biosynthesis of nanoparticles using microbes- a review. Colloids Surf B Biointerfaces. 2014; 121:474-83. DOI: 10.1016/j.colsurfb.2014.05.027. View

12.

Husain S, Sardar M, Fatma T . Screening of cyanobacterial extracts for synthesis of silver nanoparticles. World J Microbiol Biotechnol. 2015; 31(8):1279-83. DOI: 10.1007/s11274-015-1869-3. View

13.

Duran N, Seabra A . Metallic oxide nanoparticles: state of the art in biogenic syntheses and their mechanisms. Appl Microbiol Biotechnol. 2012; 95(2):275-88. DOI: 10.1007/s00253-012-4118-9. View

14.

Jia L, Zhang Q, Li Q, Song H . The biosynthesis of palladium nanoparticles by antioxidants in Gardenia jasminoides Ellis: long lifetime nanocatalysts for p-nitrotoluene hydrogenation. Nanotechnology. 2009; 20(38):385601. DOI: 10.1088/0957-4484/20/38/385601. View

15.

Nevalainen H, Suominen P, Taimisto K . On the safety of Trichoderma reesei. J Biotechnol. 1994; 37(3):193-200. DOI: 10.1016/0168-1656(94)90126-0. View

16.

Simon-Deckers A, Loo S, Mayne-LHermite M, Herlin-Boime N, Menguy N, Reynaud C . Size-, composition- and shape-dependent toxicological impact of metal oxide nanoparticles and carbon nanotubes toward bacteria. Environ Sci Technol. 2009; 43(21):8423-9. DOI: 10.1021/es9016975. View

17.

Kumar Ghosh S, Pal T . Interparticle coupling effect on the surface plasmon resonance of gold nanoparticles: from theory to applications. Chem Rev. 2007; 107(11):4797-862. DOI: 10.1021/cr0680282. View

18.

Das D, Nath B, Phukon P, Dolui S . Synthesis and evaluation of antioxidant and antibacterial behavior of CuO nanoparticles. Colloids Surf B Biointerfaces. 2012; 101:430-3. DOI: 10.1016/j.colsurfb.2012.07.002. View

19.

Mondal S, Roy N, Laskar R, Sk I, Basu S, Mandal D . Biogenic synthesis of Ag, Au and bimetallic Au/Ag alloy nanoparticles using aqueous extract of mahogany (Swietenia mahogani JACQ.) leaves. Colloids Surf B Biointerfaces. 2010; 82(2):497-504. DOI: 10.1016/j.colsurfb.2010.10.007. View

20.

Kemp M, Kumar A, Mousa S, Park T, Ajayan P, Kubotera N . Synthesis of gold and silver nanoparticles stabilized with glycosaminoglycans having distinctive biological activities. Biomacromolecules. 2009; 10(3):589-95. PMC: 2765565. DOI: 10.1021/bm801266t. View