Successful Treatment with Benralizumab for Allergic Bronchopulmonary Aspergillosis That Developed After Disastrous Heavy Rainfall in Western Japan

Overview

Journal Intern Med

Specialty General Medicine

Date 2020 Nov 16

PMID 33191330

Citations 8

Authors

Hiroaki Matsuura

Keiichi Fujiwara

Hiroki Omori

Kiriko Onishi

Tadahiro Kuribayashi

Sho Mitsumune

Yuki Takigawa

Kenichiro Kudo

Daisuke Minami

Akiko Sato

Ken Sato

Takuo Shibayama

Affiliations

Soon will be listed here.

Abstract

We herein report a 56-year-old woman who developed allergic bronchopulmonary aspergillosis (ABPA) possibly due to fungal exposure after disastrous heavy rainfall in Western Japan in 2018. She was diagnosed with ABPA complicated with asthma, increased peripheral blood eosinophil count, elevation of specific immunoglobulin E for Aspergillus fumigatus, positive Aspergillus fumigatus precipitation antibody reaction test results, and notable chest computed tomography findings. After treatment with benralizumab, her symptoms, peripheral blood eosinophil count, radiological findings, and respiratory function dramatically improved. The administration of benralizumab appears to be an effective treatment strategy for ABPA.

Citing Articles

Revised ISHAM-ABPA working group clinical practice guidelines for diagnosing, classifying and treating allergic bronchopulmonary aspergillosis/mycoses.

Agarwal R, Sehgal I, Muthu V, Denning D, Chakrabarti A, Soundappan K Eur Respir J. 2024; 63(4).

PMID: 38423624 PMC: 10991853. DOI: 10.1183/13993003.00061-2024.

Case Report: Allergic Bronchopulmonary Aspergillosis and Tropical Pulmonary Eosinophilia Co-Occurrence Masquerading as Refractory Allergic Bronchopulmonary Aspergillosis.

Singh M, Peter D, Gupta S, Rani V V, Singh S Am J Trop Med Hyg. 2024; 110(3):509-511.

PMID: 38350129 PMC: 10919194. DOI: 10.4269/ajtmh.23-0450.

Successful treatment with dupilumab in mepolizumab-resistant allergic bronchopulmonary aspergillosis.

Kawasaki Y, Nishiki K, Ishizaki T Respir Med Case Rep. 2024; 47:101964.

PMID: 38192543 PMC: 10772803. DOI: 10.1016/j.rmcr.2023.101964.

GEMA 5.3. Spanish Guideline on the Management of Asthma.

Plaza Moral V, Alobid I, Alvarez Rodriguez C, Blanco Aparicio M, Ferreira J, Garcia G Open Respir Arch. 2023; 5(4):100277.

PMID: 37886027 PMC: 10598226. DOI: 10.1016/j.opresp.2023.100277.

Real-world efficacy of anti-IL-5 treatment in patients with allergic bronchopulmonary aspergillosis.

Tomomatsu K, Yasuba H, Ishiguro T, Imokawa S, Hara J, Soeda S Sci Rep. 2023; 13(1):5468.

PMID: 37015988 PMC: 10073186. DOI: 10.1038/s41598-023-32246-8.

References

Moss R . The use of biological agents for the treatment of fungal asthma and allergic bronchopulmonary aspergillosis. Ann N Y Acad Sci. 2012; 1272:49-57. DOI: 10.1111/j.1749-6632.2012.06810.x. View

Israel E, Reddel H . Severe and Difficult-to-Treat Asthma in Adults. N Engl J Med. 2017; 377(10):965-976. DOI: 10.1056/NEJMra1608969. View

Oda N, Hirahara T, Fujioka Y, Mitani R, Takata I . Legionella Pneumonia Following the Heavy Rain Event of July 2018 in Japan. Intern Med. 2019; 58(19):2831-2834. PMC: 6815902. DOI: 10.2169/internalmedicine.2825-19. View

Bernal-Rubio L, de-la-Hoz Caballer B, Almonacid-Sanchez C, Gonzalez-De-Olano D . Successful Treatment of Allergic Bronchopulmonary Aspergillosis With Benralizumab in a Patient Who Did Not Respond to Omalizumab. J Investig Allergol Clin Immunol. 2020; 30(5):378-379. DOI: 10.18176/jiaci.0564. View

Aydin O, Celebi Sozener Z, Soyyigit S, Kendirlinan R, Gencturk Z, Misirligil Z . Omalizumab in the treatment of allergic bronchopulmonary aspergillosis: One center's experience with 14 cases. Allergy Asthma Proc. 2015; 36(6):493-500. DOI: 10.2500/aap.2015.36.3909. View

Agarwal R, Chakrabarti A, Shah A, Gupta D, Meis J, Guleria R . Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013; 43(8):850-73. DOI: 10.1111/cea.12141. View

Oshikata C, Watanabe M, Saito A, Ishida M, Kobayashi S, Konuma R . Allergic Bronchopulmonary Mycosis due to Exposure to Eurotium herbariorum after the Great East Japan Earthquake. Prehosp Disaster Med. 2017; 32(6):688-690. DOI: 10.1017/S1049023X17006914. View

Ueki S, Hebisawa A, Kitani M, Asano K, Neves J . Allergic Bronchopulmonary Aspergillosis-A Luminal Hypereosinophilic Disease With Extracellular Trap Cell Death. Front Immunol. 2018; 9:2346. PMC: 6193060. DOI: 10.3389/fimmu.2018.02346. View

Tomomatsu K, Sugino Y, Okada N, Tanaka J, Oguma T, Asano K . Rapid clearance of mepolizumab-resistant bronchial mucus plugs in allergic bronchopulmonary aspergillosis with benralizumab treatment. Allergol Int. 2020; 69(4):636-638. DOI: 10.1016/j.alit.2020.03.003. View

10.

Oguma T, Taniguchi M, Shimoda T, Kamei K, Matsuse H, Hebisawa A . Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey. Allergol Int. 2017; 67(1):79-84. DOI: 10.1016/j.alit.2017.04.011. View

11.

Altman M, Lenington J, Bronson S, Ayars A . Combination omalizumab and mepolizumab therapy for refractory allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol Pract. 2017; 5(4):1137-1139. DOI: 10.1016/j.jaip.2017.01.013. View

12.

Schoettler N, Strek M . Recent Advances in Severe Asthma: From Phenotypes to Personalized Medicine. Chest. 2019; 157(3):516-528. PMC: 7609962. DOI: 10.1016/j.chest.2019.10.009. View

13.

Davila Gonzalez I, Moreno Benitez F, Quirce S . Benralizumab: A New Approach for the Treatment of Severe Eosinophilic Asthma. J Investig Allergol Clin Immunol. 2019; 29(2):84-93. DOI: 10.18176/jiaci.0385. View

14.

Soeda S, Kono Y, Tsuzuki R, Yamawaki S, Katsube O, To M . Allergic bronchopulmonary aspergillosis successfully treated with benralizumab. J Allergy Clin Immunol Pract. 2018; 7(5):1633-1635. DOI: 10.1016/j.jaip.2018.11.024. View

15.

van der Ent C, Hoekstra H, Rijkers G . Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. Thorax. 2007; 62(3):276-7. PMC: 2117163. DOI: 10.1136/thx.2004.035519. View

16.

Hirota S, Kobayashi Y, Ishiguro T, Nishida T, Kagiyama N, Shimizu Y . Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature. Respir Med Case Rep. 2018; 26:59-62. PMC: 6263094. DOI: 10.1016/j.rmcr.2018.11.013. View

17.

Kawakami Y, Tagami T, Kusakabe T, Kido N, Kawaguchi T, Omura M . Disseminated aspergillosis associated with tsunami lung. Respir Care. 2012; 57(10):1674-8. DOI: 10.4187/respcare.01701. View

18.

Ghazi A, Trikha A, Calhoun W . Benralizumab--a humanized mAb to IL-5Rα with enhanced antibody-dependent cell-mediated cytotoxicity--a novel approach for the treatment of asthma. Expert Opin Biol Ther. 2011; 12(1):113-8. PMC: 3587289. DOI: 10.1517/14712598.2012.642359. View