YTHDC1 Mitigates Ischemic Stroke by Promoting Akt Phosphorylation Through Destabilizing PTEN MRNA

Overview

Journal Cell Death Dis

Specialties Cell Biology
General Medicine

Date 2020 Nov 14

PMID 33188203

Citations 62

Authors

Zhaolong Zhang

Qiuhan Wang

Xiaolong Zhao

Liming Shao

Guoping Liu

Xuan Zheng

Lingling Xie

Yan Zhang

Chengjian Sun

Rui Xu

Affiliations

Soon will be listed here.

Abstract

YTH Domain Containing 1 (YTHDC1) is one of the mA readers that is essential for oocyte development and tumor progression. The role of YTHDC1 in neuronal survival and ischemic stroke is unknown. Here, we found that YTHDC1 was unregulated in the early phase of ischemic stroke. Knockdown of YTHDC1 exacerbated ischemic brain injury and overexpression of YTHDC1 protected rats against brain injury. Mechanistically, YTHDC1 promoted PTEN mRNA degradation to increase Akt phosphorylation, thus facilitating neuronal survival in particular after ischemia. These data identify YTHDC1 as a novel regulator of neuronal survival and modulating mA reader YTHDC1 may provide a potential therapeutic target for ischemic stroke.

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