Pharmacologic Aspects of S-adenosylmethionine. Pharmacokinetics and Pharmacodynamics

Several studies in animals have shown the efficacy of parenteral S-adenosylmethionine (SAMe) as an anti-inflammatory drug. In this article, data are reported on plasma kinetics, distribution, and metabolism of SAMe after oral administration since preference is given to oral dosage in the usual clinical practice. The results demonstrate the intestinal absorption of SAMe and its active metabolism. Experiments confirm the anti-inflammatory activity of the drug by the oral route. Results are also reported on the analgesic effect of SAMe.