Necrostatin-1 and Necroptosis Inhibition: Pathophysiology and Therapeutic Implications

Overview

Journal Pharmacol Res

Publisher Elsevier

Specialty Pharmacology

Date 2020 Nov 12

PMID 33181319

Citations 98

Authors

Liyuan Cao

Wei Mu

Affiliations

Soon will be listed here.

Abstract

Necrostatin-1 (Nec-1) is a RIP1-targeted inhibitor of necroptosis, a form of programmed cell death discovered and investigated in recent years. There are already many studies demonstrating the essential role of necroptosis in various diseases, including inflammatory diseases, cardiovascular diseases and neurological diseases. However, the potential of Nec-1 in diseases has not received much attention. Nec-1 is able to inhibit necroptosis signaling pathway and thus ameliorate necroptotic cell death in disease development. Recent research findings indicate that Nec-1 could be applied in several types of diseases to alleviate disease development or improve prognosis. Moreover, we predict that Nec-1 has the potential to protect against the complications of coronavirus disease 2019 (COVID-19). This review summarized the effect of Nec-1 in disease models and the underlying molecular mechanism, providing research evidence for its future application.

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