Yes-Associated Protein 1: Role and Treatment Prospects in Orthopedic Degenerative Diseases

Overview

Journal Front Cell Dev Biol

Specialty Cell Biology

Date 2020 Nov 12

PMID 33178690

Citations 13

Authors

Wenqing Xie

Wenfeng Xiao

Kun Tang

Liyang Zhang

Yusheng Li

Affiliations

Soon will be listed here.

Abstract

The Hippo/yes-associated protein 1 signaling pathway is an evolutionarily conserved signaling pathway. This signaling pathway is primarily involved in the regulation of stem cell self-renewal, organ size and tissue regeneration by regulating cell proliferation, differentiation and apoptosis. It plays an important role in embryonic development and tissue organ formation. Yes-associated protein 1 (YAP1) is a key transcription factor in the Hippo signaling pathway and is negatively regulated by this pathway. Changes in YAP1 expression levels affect the occurrence and development of a variety of tumors, but the specific mechanism associated with this phenomenon has not been thoroughly studied. Recently, several studies have described the role of YAP1 in osteoarthritis (OA). Indeed, YAP1 is involved in orthopedic degenerative diseases such as osteoporosis (OP) in addition to OA. In this review, we will summarize the significance of YAP1 in orthopedic degenerative diseases and discuss the potential of the targeted modulation of YAP1 for the treatment of these diseases.

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