Redesigning Nature's Poisons to Create Anti-tumor Reagents

Overview

Journal Science

Specialty Science

Date 1987 Nov 20

PMID 3317828

Citations 48

Authors

E S Vitetta

R J Fulton

R D May

M Till

J W UHR

Affiliations

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Abstract

Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

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