Development of the Primary Antibody Repertoire

Overview

Journal Science

Specialty Science

Date 1987 Nov 20

PMID 3317825

Citations 168

Authors

F W Alt

T K Blackwell

G D Yancopoulos

Affiliations

Soon will be listed here.

Abstract

The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.

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