Oxidative Stress in the Light-exposed Retina and Its Implication in Age-related Macular Degeneration

Overview

Journal Redox Biol

Specialties Biology
Cell Biology
Endocrinology

Date 2020 Nov 11

PMID 33172789

Citations 54

Authors

Yoko Ozawa

Affiliations

Soon will be listed here.

Abstract

The retina continuously receives light to enable vision, and the related processes require a marked amount of energy. During active metabolism, reactive oxygen species (ROS) are generated in exchange. Although physiologically generated ROS may be removed by endogenous antioxidant systems, and the effects of oxidative stress may be recovered by repair systems to retain homeostasis and health, when ROS and oxidative stress exceed the capacity of the antioxidant and repair systems, the condition becomes pathological. Multiple mechanisms of oxidative stress and the effects of antioxidant and repair systems in the retina have long been analyzed using light-induced retinal degeneration models. Among the mechanisms, a positive feedback loop of oxidative stress and related inflammation may be involved in the pathogenesis of a blinding aging disease, age-related macular degeneration. Treatments for suppressing ROS and oxidative stress by administrating antioxidant products may support the tissue-protective function of antioxidant systems. Moreover, recent studies have proposed a new concept for maintaining homeostasis by supplying sufficient energy to activate the repair systems. The current review will help elucidate the influence of oxidative stress and guide future analyses to explore new therapeutic approaches for oxidative stress-mediated diseases.

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References

Nagai N, Asato T, Minami S, Suzuki M, Shinoda H, Kurihara T . Correlation between Macular Pigment Optical Density and Neural Thickness and Volume of the Retina. Nutrients. 2020; 12(4). PMC: 7230595. DOI: 10.3390/nu12040888. View

Chen Y, Sawada O, Kohno H, Le Y, Subauste C, Maeda T . Autophagy protects the retina from light-induced degeneration. J Biol Chem. 2013; 288(11):7506-7518. PMC: 3597791. DOI: 10.1074/jbc.M112.439935. View

Harris J, Jolivet R, Attwell D . Synaptic energy use and supply. Neuron. 2012; 75(5):762-77. DOI: 10.1016/j.neuron.2012.08.019. View

Hurley J, Lindsay K, Du J . Glucose, lactate, and shuttling of metabolites in vertebrate retinas. J Neurosci Res. 2015; 93(7):1079-92. PMC: 4720126. DOI: 10.1002/jnr.23583. View

Miyake S, Kobayashi S, Tsubota K, Ozawa Y . Phase II enzyme induction by a carotenoid, lutein, in a PC12D neuronal cell line. Biochem Biophys Res Commun. 2014; 446(2):535-40. DOI: 10.1016/j.bbrc.2014.02.135. View

Nakamura M, Kuse Y, Tsuruma K, Shimazawa M, Hara H . The Involvement of the Oxidative Stress in Murine Blue LED Light-Induced Retinal Damage Model. Biol Pharm Bull. 2017; 40(8):1219-1225. DOI: 10.1248/bpb.b16-01008. View

Narimatsu T, Negishi K, Miyake S, Hirasawa M, Osada H, Kurihara T . Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo. Exp Eye Res. 2015; 132:48-51. DOI: 10.1016/j.exer.2015.01.003. View

. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013; 309(19):2005-15. DOI: 10.1001/jama.2013.4997. View

Muraoka Y, Iida Y, Ikeda H, Iwai S, Hata M, Iwata T . KUS121, an ATP regulator, mitigates chorioretinal pathologies in animal models of age-related macular degeneration. Heliyon. 2018; 4(5):e00624. PMC: 5986307. DOI: 10.1016/j.heliyon.2018.e00624. View

10.

Krinsky N, Landrum J, Bone R . Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr. 2003; 23:171-201. DOI: 10.1146/annurev.nutr.23.011702.073307. View

11.

YOUNG A, Lowe G . Antioxidant and prooxidant properties of carotenoids. Arch Biochem Biophys. 2001; 385(1):20-7. DOI: 10.1006/abbi.2000.2149. View

12.

Nakazawa M, Maeda S, Yokoyama N, Nakagawa T, Yonezawa T, Ohno K . Sphingosine-1-phosphate (S1P) signaling regulates the production of intestinal IgA and its potential role in the pathogenesis of canine inflammatory bowel disease. J Vet Med Sci. 2019; 81(9):1249-1258. PMC: 6785611. DOI: 10.1292/jvms.19-0016. View

13.

Ban N, Ozawa Y, Osada H, Lin J, Toda E, Watanabe M . Neuroprotective role of retinal SIRT3 against acute photo-stress. NPJ Aging Mech Dis. 2017; 3:19. PMC: 5712523. DOI: 10.1038/s41514-017-0017-8. View

14.

Nagai N, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H . Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration. J Clin Med. 2020; 9(5). PMC: 7290696. DOI: 10.3390/jcm9051347. View

15.

Narimatsu T, Ozawa Y, Miyake S, Kubota S, Hirasawa M, Nagai N . Disruption of cell-cell junctions and induction of pathological cytokines in the retinal pigment epithelium of light-exposed mice. Invest Ophthalmol Vis Sci. 2013; 54(7):4555-62. DOI: 10.1167/iovs.12-11572. View

16.

Narimatsu T, Ozawa Y, Miyake S, Nagai N, Tsubota K . Angiotensin II type 1 receptor blockade suppresses light-induced neural damage in the mouse retina. Free Radic Biol Med. 2014; 71:176-185. DOI: 10.1016/j.freeradbiomed.2014.03.020. View

17.

Domenech E, Marfany G . The Relevance of Oxidative Stress in the Pathogenesis and Therapy of Retinal Dystrophies. Antioxidants (Basel). 2020; 9(4). PMC: 7222416. DOI: 10.3390/antiox9040347. View

18.

Rozing M, Durhuus J, Krogh Nielsen M, Subhi Y, Kirkwood T, Westendorp R . Age-related macular degeneration: A two-level model hypothesis. Prog Retin Eye Res. 2020; 76:100825. DOI: 10.1016/j.preteyeres.2019.100825. View

19.

Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K . Neuroprotective effects of lutein in the retina. Curr Pharm Des. 2012; 18(1):51-6. PMC: 3319923. DOI: 10.2174/138161212798919101. View

20.

. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001; 119(10):1417-36. PMC: 1462955. DOI: 10.1001/archopht.119.10.1417. View