Massive Relief: Papillary Adenoma of the Lung in Asymptomatic Former Smoker Patient
Overview
Affiliations
Benign epithelial tumors of the lung are uncommon and can represent a diagnostic challenge. Herein, we describe one such emblematic case. A 59-year-old former smoker male was admitted to the hospital complaining of cough for a long time. A radiological examination showed a centrally excavated mass strictly connected to the visceral pleura. The patient underwent tumorectomy. At gross examination, the tumor was composed of solid and cystic areas containing clear liquid. Histological examination highlighted a sub-pleural encapsulated tumor, with foci of capsular invasion, characterized by a single layer of columnar and cuboidal epithelial cells lining moderately cellular fibro-vascular cores. A wide spectrum of immunohistochemical markers was performed. The final diagnosis was suggestive of a peripheral pulmonary papillary tumor of undetermined malignant potential. At the last follow-up, six years after surgery, no recurrence or metastases were described. Reporting this case, we would like to point out the existence of these rare entities that should be taken into account in the diagnostic process, thus avoiding potential misdiagnosis. Moreover, the presence of capsular invasion should be better investigated in order to reconsider the exact terminology of the tumor and the classification of its malignant potential.
Papillary adenoma of the lung: A case report and literature review.
Chen L, Yang M, Gao S, Wang Z, Xu H Exp Ther Med. 2024; 28(3):369.
PMID: 39091411 PMC: 11292175. DOI: 10.3892/etm.2024.12658.
Pulmonary papillary adenoma with malignant potential: a case report and literature review.
Liu P, Feng J, Yang M, Chen J, Fu L, Lu J Diagn Pathol. 2022; 17(1):81.
PMID: 36229884 PMC: 9563795. DOI: 10.1186/s13000-022-01259-8.