DNA Methylation and Epigenetic Defects in Carcinogenesis

Overview

Journal Mutat Res

Publisher Elsevier

Specialty Genetics

Date 1987 Dec 1

PMID 3317024

Citations 20

Authors

R Holliday

Affiliations

Soon will be listed here.

Abstract

It is frequently assumed that DNA-damaging agents are carcinogenic because they induce mutations. However, another strong possibility is that the damage leads to heritable changes in the methylation of cytosine in DNA. Considerable evidence exists that gene expression in mammalian cells is in part controlled by methylation of specific DNA sequences. Carcinogens may act by altering the normal epigenetic controls of gene activity in specialised cells, and thereby produce aberrant heritable phenotypes. It is known that agents which inhibit DNA methylation can be carcinogenic and that tumour cells are altered in DNA methylation.

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