Photobiomodulation by a New Optical Fiber Device: Analysis of the in Vitro Impact on Proliferation/migration of Keratinocytes and Squamous Cell Carcinomas Cells Stressed by X-rays

Overview

Journal Lasers Med Sci

Publisher Springer

Date 2020 Nov 10

PMID 33169275

Citations 1

Authors

Elodie Courtois

Jean-Baptiste Guy

Fabrice Axisa

Pierre Saint-Girons

Laure Alston

Narimene Houmera

Rene-Jean Bensadoun

Anne Visbecq

Claire Rodriguez-Lafrasse

Nicolas Magne

Affiliations

Soon will be listed here.

Abstract

Photobiomodulation-based (PBM-based) therapies show promising results in mucositis and dermatitis treatment by stimulating wound healing mechanisms such as cell proliferation and migration. The aim of the present study is to investigate the in vitro effects of CareMin650 on the proliferation and migration of two different types of cells, namely cancer and non-cancer cells, with or without X-ray radiation. Study design used PBM through a combination of 0-3-6 J/cm doses-with or without X-ray radiation-on the proliferation and migration capabilities of a keratinocyte cell line (HaCaT) and a squamous cell carcinoma line (SCC61). PBM is delivered by a new woven optical fiber device, namely CareMin650 prototype (light emission by LEDs (light-emitting diodes), peak at 660 nm, irradiance of 21.6 mW/cm). The effectiveness of PBM to increase HaCaT proliferation and migration (with or without X-ray radiation) supports the capability of PBM to favor wound healing. It also highlights that PBM does not provide any anti-radiation effect to previously X-rays radiated SCC (p < 0.001). Such data supports the beneficial effect of PBM delivered by an optical fiber device to heal wounds, without promoting cancer development.

Citing Articles

Effect of low-level light therapy before radiotherapy in oral squamous cell carcinoma: An in vitro study.

Lima Tabosa A, Souza M, de Jesus S, Rocha D, Queiroz L, Santos E Lasers Med Sci. 2022; 37(9):3527-3536.

PMID: 36001245 DOI: 10.1007/s10103-022-03632-x.

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