Differential Effects of Intervention Timing on COVID-19 Spread in the United States

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2020 Nov 7

PMID 33158911

Citations 175

Authors

Sen Pei

Sasikiran Kandula

Jeffrey Shaman

Affiliations

Soon will be listed here.

Abstract

Assessing the effects of early nonpharmaceutical interventions on coronavirus disease 2019 (COVID-19) spread is crucial for understanding and planning future control measures to combat the pandemic. We use observations of reported infections and deaths, human mobility data, and a metapopulation transmission model to quantify changes in disease transmission rates in U.S. counties from 15 March to 3 May 2020. We find that marked, asynchronous reductions of the basic reproductive number occurred throughout the United States in association with social distancing and other control measures. Counterfactual simulations indicate that, had these same measures been implemented 1 to 2 weeks earlier, substantial cases and deaths could have been averted and that delayed responses to future increased incidence will facilitate a stronger rebound of infections and death. Our findings underscore the importance of early intervention and aggressive control in combatting the COVID-19 pandemic.

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References

Pei S, Kandula S, Yang W, Shaman J . Forecasting the spatial transmission of influenza in the United States. Proc Natl Acad Sci U S A. 2018; 115(11):2752-2757. PMC: 5856508. DOI: 10.1073/pnas.1708856115. View

Tian H, Liu Y, Li Y, Wu C, Chen B, Kraemer M . An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China. Science. 2020; 368(6491):638-642. PMC: 7164389. DOI: 10.1126/science.abb6105. View

Verity R, Okell L, Dorigatti I, Winskill P, Whittaker C, Imai N . Estimates of the severity of coronavirus disease 2019: a model-based analysis. Lancet Infect Dis. 2020; 20(6):669-677. PMC: 7158570. DOI: 10.1016/S1473-3099(20)30243-7. View

DeFelice N, Little E, Campbell S, Shaman J . Ensemble forecast of human West Nile virus cases and mosquito infection rates. Nat Commun. 2017; 8:14592. PMC: 5333106. DOI: 10.1038/ncomms14592. View

He X, Lau E, Wu P, Deng X, Wang J, Hao X . Temporal dynamics in viral shedding and transmissibility of COVID-19. Nat Med. 2020; 26(5):672-675. DOI: 10.1038/s41591-020-0869-5. View

Chinazzi M, Davis J, Ajelli M, Gioannini C, Litvinova M, Merler S . The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak. Science. 2020; 368(6489):395-400. PMC: 7164386. DOI: 10.1126/science.aba9757. View

Maier B, Brockmann D . Effective containment explains subexponential growth in recent confirmed COVID-19 cases in China. Science. 2020; 368(6492):742-746. PMC: 7164388. DOI: 10.1126/science.abb4557. View

Pei S, Shaman J . Counteracting structural errors in ensemble forecast of influenza outbreaks. Nat Commun. 2017; 8(1):925. PMC: 5640637. DOI: 10.1038/s41467-017-01033-1. View

Ferretti L, Wymant C, Kendall M, Zhao L, Nurtay A, Abeler-Dorner L . Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing. Science. 2020; 368(6491). PMC: 7164555. DOI: 10.1126/science.abb6936. View

10.

Heaney A, Alexander K, Shaman J . Ensemble forecast and parameter inference of childhood diarrhea in Chobe District, Botswana. Epidemics. 2019; 30:100372. PMC: 7669214. DOI: 10.1016/j.epidem.2019.100372. View

11.

Havers F, Reed C, Lim T, Montgomery J, Klena J, Hall A . Seroprevalence of Antibodies to SARS-CoV-2 in 10 Sites in the United States, March 23-May 12, 2020. JAMA Intern Med. 2020; . DOI: 10.1001/jamainternmed.2020.4130. View

12.

Diekmann O, Heesterbeek J, Roberts M . The construction of next-generation matrices for compartmental epidemic models. J R Soc Interface. 2009; 7(47):873-85. PMC: 2871801. DOI: 10.1098/rsif.2009.0386. View

13.

Zhang J, Litvinova M, Liang Y, Wang Y, Wang W, Zhao S . Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China. Science. 2020; 368(6498):1481-1486. PMC: 7199529. DOI: 10.1126/science.abb8001. View

14.

Hsiang S, Allen D, Annan-Phan S, Bell K, Bolliger I, Chong T . The effect of large-scale anti-contagion policies on the COVID-19 pandemic. Nature. 2020; 584(7820):262-267. DOI: 10.1038/s41586-020-2404-8. View

15.

Li R, Pei S, Chen B, Song Y, Zhang T, Yang W . Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2). Science. 2020; 368(6490):489-493. PMC: 7164387. DOI: 10.1126/science.abb3221. View

16.

Holshue M, DeBolt C, Lindquist S, Lofy K, Wiesman J, Bruce H . First Case of 2019 Novel Coronavirus in the United States. N Engl J Med. 2020; 382(10):929-936. PMC: 7092802. DOI: 10.1056/NEJMoa2001191. View

17.

Perkins T, Cavany S, Moore S, Oidtman R, Lerch A, Poterek M . Estimating unobserved SARS-CoV-2 infections in the United States. Proc Natl Acad Sci U S A. 2020; 117(36):22597-22602. PMC: 7486725. DOI: 10.1073/pnas.2005476117. View

18.

Dehning J, Zierenberg J, Spitzner F, Wibral M, Neto J, Wilczek M . Inferring change points in the spread of COVID-19 reveals the effectiveness of interventions. Science. 2020; 369(6500). PMC: 7239331. DOI: 10.1126/science.abb9789. View

19.

Baker R, Yang W, Vecchi G, Metcalf C, Grenfell B . Susceptible supply limits the role of climate in the early SARS-CoV-2 pandemic. Science. 2020; 369(6501):315-319. PMC: 7243362. DOI: 10.1126/science.abc2535. View

20.

Lai S, Ruktanonchai N, Zhou L, Prosper O, Luo W, Floyd J . Effect of non-pharmaceutical interventions to contain COVID-19 in China. Nature. 2020; 585(7825):410-413. PMC: 7116778. DOI: 10.1038/s41586-020-2293-x. View