Evaluation of Effect of a Vitamin-based Barrier Cream on the Clinical Severity of Actinic Cheilitis: A Preliminary Study

Overview

Journal J Clin Exp Dent

Specialty Dentistry

Date 2020 Nov 6

PMID 33154796

Authors

Mariana-Sudati Rodrigues

Eduardo-Oliveira Kaefer

Juliana-Tomaz Sganzerla

Humberto-Thomazi Gassen

Rubem-Beraldo Dos Santos

Sergio-Augusto-Quevedo Miguens-Jr

Affiliations

Soon will be listed here.

Abstract

Background: Actinic Cheilitis (AC) is a pathological condition of the labial mucosa considered potentially malignant. The aim of this study was to investigate the effect of treatment of AC with daily use of a vitamin-based barrier cream.

Material And Methods: For this clinical study, 36 participants with lower-lip AC were recruited from three oral medicine services. At baseline, participants were evaluated by clinical examination and clinical severity of AC was classified as grade I to IV. All participants were dispensed a tube of a barrier cream containing vitamins A, D, E and ZnO to apply once nightly for 90 consecutive days. Monthly follow-up was performed to reclassify AC clinial severity. The primary outcome of interest was clinical remission of AC at 90-day follow-up compared to baseline.

Results: Progressive remission of AC lesions was observed as early as the first month and throughout the assessment period ( = 0.000). The 3-month period was insufficient for remission of lesions, especially among male participants ( = 0.002) and with a longer sun exposure in years ( = 0.007).

Conclusions: Daily use of the vitamin-based barrier cream had a promissing positive impact on the severity of actinic cheilitis. However, a 90-day course of treatment was not sufficient to achieve lesions remission. The findings of this study suggest a promising new avenue for the treatment of lower-lip AC. Actinic cheilitis, vitamins, retinoids, vitamin D, therapeutics.

References

Poitevin N, Rodrigues M, Weigert K, Macedo C, Dos Santos R . Actinic cheilitis: proposition and reproducibility of a clinical criterion. BDJ Open. 2018; 3:17016. PMC: 5842833. DOI: 10.1038/bdjopen.2017.16. View

Dancyger A, Heard V, Huang B, Suley C, Tang D, Ariyawardana A . Malignant transformation of actinic cheilitis: A systematic review of observational studies. J Investig Clin Dent. 2018; 9(4):e12343. DOI: 10.1111/jicd.12343. View

McDaniel D, Mazur C, Wortzman M, Nelson D . Efficacy and tolerability of a double-conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging. J Cosmet Dermatol. 2017; 16(4):542-548. DOI: 10.1111/jocd.12381. View

Chaithirayanon S . Comparative Study between Talcum and Zinc Oxide Cream for the Prevention of Irritant Contact Diaper Dermatitis in Infants. J Med Assoc Thai. 2018; 99 Suppl 8:S1-S6. View

Sotiriou E, Lallas A, Goussi C, Apalla Z, Trigoni A, Chovarda E . Sequential use of photodynamic therapy and imiquimod 5% cream for the treatment of actinic cheilitis: a 12-month follow-up study. Br J Dermatol. 2011; 165(4):888-92. DOI: 10.1111/j.1365-2133.2011.10478.x. View

Rodriguez-Blanco I, Florez A, Paredes-Suarez C, Rodriguez-Lojo R, Gonzalez-Vilas D, Ramirez-Santos A . Actinic Cheilitis Prevalence and Risk Factors: A Cross-sectional, Multicentre Study in a Population Aged 45 Years and Over in North-west Spain. Acta Derm Venereol. 2018; 98(10):970-974. DOI: 10.2340/00015555-3014. View

Sumita J, Miot H, Soares J, Raminelli A, Pereira S, Ogawa M . Tretinoin (0.05% cream vs. 5% peel) for photoaging and field cancerization of the forearms: randomized, evaluator-blinded, clinical trial. J Eur Acad Dermatol Venereol. 2018; 32(10):1819-1826. DOI: 10.1111/jdv.15020. View

Dalvi V, Mekoth N . Regimen Difficulty and Medication Non-Adherence and the Interaction Effects of Gender and Age. Hosp Top. 2017; 96(2):35-41. DOI: 10.1080/00185868.2017.1385361. View

Rodriguez-Blanco I, Florez A, Paredes-Suarez C, Rodriguez-Lojo R, Gonzalez-Vilas D, Ramirez-Santos A . Use of lip photoprotection in patients suffering from actinic cheilitis. Eur J Dermatol. 2019; 29(4):383-386. DOI: 10.1684/ejd.2019.3604. View

10.

Langberg M, Rotem C, Fenig E, Koren R, Ravid A . Vitamin D protects keratinocytes from deleterious effects of ionizing radiation. Br J Dermatol. 2008; 160(1):151-61. DOI: 10.1111/j.1365-2133.2008.08797.x. View

11.

Russell M . Assessing the relationship between vitamin D3 and stratum corneum hydration for the treatment of xerotic skin. Nutrients. 2012; 4(9):1213-8. PMC: 3475231. DOI: 10.3390/nu4091213. View

12.

Cunningham T, Tabacchi M, Eliane J, Moradi Tuchayi S, Manivasagam S, Mirzaalian H . Randomized trial of calcipotriol combined with 5-fluorouracil for skin cancer precursor immunotherapy. J Clin Invest. 2016; 127(1):106-116. PMC: 5199703. DOI: 10.1172/JCI89820. View

13.

Gupta A, Paquet M, Villanueva E, Brintnell W . Interventions for actinic keratoses. Cochrane Database Syst Rev. 2012; 12:CD004415. PMC: 6599879. DOI: 10.1002/14651858.CD004415.pub2. View

14.

Gheno J, Martins M, Munerato M, Hugo F, Filho M, Weissheimer C . Oral mucosal lesions and their association with sociodemographic, behavioral, and health status factors. Braz Oral Res. 2015; 29. DOI: 10.1590/1807-3107BOR-2015.vol29.0093. View

15.

Ferreira A, de Souza Lucena E, de Oliveira T, da Silveira E, de Oliveira P, de Lima K . Prevalence and factors associated with oral potentially malignant disorders in Brazil's rural workers. Oral Dis. 2016; 22(6):536-42. DOI: 10.1111/odi.12488. View

16.

Choi S, Kim K, Song K . Efficacy of ablative fractional laser-assisted photodynamic therapy for the treatment of actinic cheilitis: 12-month follow-up results of a prospective, randomized, comparative trial. Br J Dermatol. 2014; 173(1):184-91. DOI: 10.1111/bjd.13542. View

17.

van der Waal I . Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 2008; 45(4-5):317-23. DOI: 10.1016/j.oraloncology.2008.05.016. View

18.

Salgueiro A, de Jesus L, de Souza I, Rados P, Visioli F . Treatment of actinic cheilitis: a systematic review. Clin Oral Investig. 2019; 23(5):2041-2053. DOI: 10.1007/s00784-019-02895-z. View

19.

Grimm M, Cetindis M, Biegner T, Lehman M, Munz A, Teriete P . Serum vitamin D levels of patients with oral squamous cell carcinoma (OSCC) and expression of vitamin D receptor in oral precancerous lesions and OSCC. Med Oral Patol Oral Cir Bucal. 2015; 20(2):e188-95. PMC: 4393981. DOI: 10.4317/medoral.20368. View

20.

Lupu M, Caruntu A, Caruntu C, Boda D, Moraru L, Voiculescu V . Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip. Mol Clin Oncol. 2018; 8(5):640-646. PMC: 5920479. DOI: 10.3892/mco.2018.1599. View