CLC-3 and SOX2 Regulate the Cell Cycle in DU145 Cells

Overview

Journal Oncol Lett

Specialty Oncology

Date 2020 Nov 6

PMID 33154770

Citations 2

Authors

Jiahong Chen

Fang Wang

Yuli Lu

Shangqi Yang

Xueqin Chen

Youwei Huang

Xi Lin

Affiliations

Soon will be listed here.

Abstract

Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully understood. The present study investigated the association between SOX2 and chloride voltage-gated channel 3 (CLC-3) in prostate cancer. Flow cytometry demonstrated that the inactivation of CLC-3 or SOX2 arrested cell cycle progression in the G/G phase. Furthermore, CLC-3 was observed to bind to SOX2, and vice versa, by co-immunoprecipitation. SOX2 appears to initiate and maintain prostate cancer tumorigenesis, in part, by modulating the cell cycle. These findings indicate the potential of SOX2 and CLC-3 as targets for the development of multi-targeted therapeutics.

Citing Articles

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