Impact of Acute Exercise on Immediate and Following Early Post-exercise FGF-21 Concentration in Adults: Systematic Review and Meta-analysis

Overview

Journal Hormones (Athens)

Specialty Endocrinology

Date 2020 Nov 5

PMID 33151509

Citations 17

Authors

Mousa Khalafi

Karim Azali Alamdari

Michael E Symonds

Hadi Nobari

Jorge Carlos-Vivas

Affiliations

Soon will be listed here.

Abstract

Purpose/objective: The aim of this study was to quantify circulating fibroblast growth factor 21 (FGF-21) changes during and immediately after acute exercise and, based on body weight, to identify the subgroups exhibiting the largest response.

Methods: The PubMed, Web of Science, and Cochrane Library electronic databases were searched up to December 2019 for studies published in English peer-reviewed journals. Studies that evaluated the effects of acute exercise on FGF-21 concentrations immediately after and 1 and 3 h post-exercise in adults were included. Random effects models were used for analyses, with data reported as standardized mean difference (SMD) and 95% confidence interval, and the risk of heterogeneity was evaluated. Subgroup analysis of subjects with normal weight and obesity/overweight was performed.

Results: A total of seven studies involving 125 participants (age 35.95 (21-64) years and BMI 25.89 (21.30-35.46) kg/m) were included. Overall, acute exercise increased FGF-21 (d = 0.18; 95% CI 0.01 to 0.35, p = 0.02) and this remained for 1 h post-exercise FGF-21 (d = 0.59; 95% CI 0.33 to 0.86, p = 0.001). Three hours after exercise, FGF-21 was restored to near baseline values (d = - 0.05; 95% CI - 0.34 to 0.22, p = 0.68). Acute exercise raised FGF-21 concentrations in normal weight participants (d = 0.57, p = 0.001) and tended to increase in overweight and obese participants (d = 0.79, p = 0.05) 1 h post-exercise.

Conclusion: Acute exercise increases circulating FGF-21, irrespective of body weight.

Citing Articles

Myokines May Be the Answer to the Beneficial Immunomodulation of Tailored Exercise-A Narrative Review.

Lu Z, Wang Z, Zhang X, Ning K Biomolecules. 2024; 14(10).

PMID: 39456138 PMC: 11506288. DOI: 10.3390/biom14101205.

Change of Fibroblast Growth Factor 21 Level Correlates with the Severity of Diabetic Sensory Polyneuropathy after Six-Week Physical Activity.

Molnar A, Szentpeteri A, Lorincz H, Seres I, Harangi M, Balogh Z Rev Cardiovasc Med. 2024; 23(5):160.

PMID: 39077619 PMC: 11273855. DOI: 10.31083/j.rcm2305160.

The effects of exercise on FGF21 in adults: a systematic review and meta-analysis.

Liu C, Yan X, Zong Y, He Y, Yang G, Xiao Y PeerJ. 2024; 12:e17615.

PMID: 38948228 PMC: 11212618. DOI: 10.7717/peerj.17615.

Exploring exercise-driven exerkines: unraveling the regulation of metabolism and inflammation.

Zhou N, Gong L, Zhang E, Wang X PeerJ. 2024; 12:e17267.

PMID: 38699186 PMC: 11064867. DOI: 10.7717/peerj.17267.

Combined effects of exercise and different levels of acute hypoxic severity: A randomized crossover study on glucose regulation in adults with overweight.

Tee C, Parr E, Cooke M, Chong M, Rahmat N, Md Razali M Front Physiol. 2023; 14:1174926.

PMID: 37123278 PMC: 10133678. DOI: 10.3389/fphys.2023.1174926.

References

Huang Z, Xu A, Cheung B . The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension. Curr Hypertens Rep. 2017; 19(4):28. DOI: 10.1007/s11906-017-0730-5. View

BonDurant L, Ameka M, Naber M, Markan K, Idiga S, Acevedo M . FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms. Cell Metab. 2017; 25(4):935-944.e4. PMC: 5494834. DOI: 10.1016/j.cmet.2017.03.005. View

Cuevas-Ramos D, Almeda-Valdes P, Aguilar-Salinas C, Cuevas-Ramos G, Cuevas-Sosa A, Gomez-Perez F . The role of fibroblast growth factor 21 (FGF21) on energy balance, glucose and lipid metabolism. Curr Diabetes Rev. 2009; 5(4):216-20. DOI: 10.2174/157339909789804396. View

Singhal G, Fisher F, Chee M, Tan T, El Ouaamari A, Adams A . Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS One. 2016; 11(2):e0148252. PMC: 4752212. DOI: 10.1371/journal.pone.0148252. View

Fisher F, Maratos-Flier E . Understanding the Physiology of FGF21. Annu Rev Physiol. 2015; 78:223-41. DOI: 10.1146/annurev-physiol-021115-105339. View

Schlein C, Talukdar S, Heine M, Fischer A, Krott L, Nilsson S . FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues. Cell Metab. 2016; 23(3):441-53. DOI: 10.1016/j.cmet.2016.01.006. View

Cuevas-Ramos D, Mehta R, Aguilar-Salinas C . Fibroblast Growth Factor 21 and Browning of White Adipose Tissue. Front Physiol. 2019; 10:37. PMC: 6370737. DOI: 10.3389/fphys.2019.00037. View

Su X, Kong Y, Peng D . Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease. Clin Chim Acta. 2019; 498:30-37. DOI: 10.1016/j.cca.2019.08.005. View

Badman M, Pissios P, Kennedy A, Koukos G, Flier J, Maratos-Flier E . Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab. 2007; 5(6):426-37. DOI: 10.1016/j.cmet.2007.05.002. View

10.

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V . Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab. 2007; 5(6):415-25. DOI: 10.1016/j.cmet.2007.05.003. View

12.

Oost L, Kustermann M, Armani A, Blaauw B, Romanello V . Fibroblast growth factor 21 controls mitophagy and muscle mass. J Cachexia Sarcopenia Muscle. 2019; 10(3):630-642. PMC: 6596457. DOI: 10.1002/jcsm.12409. View

13.

Berti L, Irmler M, Zdichavsky M, Meile T, Bohm A, Stefan N . Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretion of human abdominal subcutaneous adipocytes. Mol Metab. 2015; 4(7):519-27. PMC: 4481465. DOI: 10.1016/j.molmet.2015.04.002. View

14.

Chen C, Cheung B, Tso A, Wang Y, Law L, Ong K . High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects. Diabetes Care. 2011; 34(9):2113-5. PMC: 3161267. DOI: 10.2337/dc11-0294. View

15.

Li H, Dong K, Fang Q, Hou X, Zhou M, Bao Y . High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China. J Hepatol. 2012; 58(3):557-63. DOI: 10.1016/j.jhep.2012.10.029. View

17.

Slusher A, Whitehurst M, Zoeller R, Mock J, Maharaj M, Huang C . Attenuated fibroblast growth factor 21 response to acute aerobic exercise in obese individuals. Nutr Metab Cardiovasc Dis. 2015; 25(9):839-845. DOI: 10.1016/j.numecd.2015.06.002. View

18.

Willis S, Sargeant J, Thackray A, Yates T, Stensel D, Aithal G . Effect of exercise intensity on circulating hepatokine concentrations in healthy men. Appl Physiol Nutr Metab. 2019; 44(10):1065-1072. DOI: 10.1139/apnm-2018-0818. View

19.

Pedersen B, Saltin B . Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015; 25 Suppl 3:1-72. DOI: 10.1111/sms.12581. View

20.

Romero-Gomez M, Zelber-Sagi S, Trenell M . Treatment of NAFLD with diet, physical activity and exercise. J Hepatol. 2017; 67(4):829-846. DOI: 10.1016/j.jhep.2017.05.016. View

21.

Huh J . The role of exercise-induced myokines in regulating metabolism. Arch Pharm Res. 2017; 41(1):14-29. DOI: 10.1007/s12272-017-0994-y. View

22.

Takahashi H, Alves C, Stanford K, Middelbeek R, Nigro P, Ryan R . TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nat Metab. 2019; 1(2):291-303. PMC: 6481955. DOI: 10.1038/s42255-018-0030-7. View