Neutrophil Extracellular Traps and Thrombosis in COVID-19

Overview

Journal J Thromb Thrombolysis

Specialty Cardiology & Vascular Diseases

Date 2020 Nov 5

PMID 33151461

Citations 165

Authors

Yu Zuo

Melanie Zuo

Srilakshmi Yalavarthi

Kelsey Gockman

Jacqueline A Madison

Hui Shi

Wrenn Woodard

Sean P Lezak

Njira L Lugogo

Jason S Knight

Yogendra Kanthi

Affiliations

Soon will be listed here.

Abstract

Studies of patients with COVID-19 have demonstrated markedly dysregulated coagulation and a high risk of morbid arterial and venous thrombotic events. Elevated levels of blood neutrophils and neutrophil extracellular traps (NETs) have recently been described in patients with COVID-19. However, their potential role in COVID-19-associated thrombosis remains incompletely understood. In order to elucidate the potential role of hyperactive neutrophils and NET release in COVID-19-associated thrombosis, we conducted a case-control study of patients hospitalized with COVID-19 who developed thrombosis, as compared with gender- and age-matched COVID-19 patients without clinical thrombosis. We found that remnants of NETs (cell-free DNA, myeloperoxidase-DNA complexes, and citrullinated histone H3) and neutrophil-derived S100A8/A9 (calprotectin) in patient sera were associated with higher risk of morbid thrombotic events in spite of prophylactic anticoagulation. These observations underscore the need for urgent investigation into the potential relationship between NETs and unrelenting thrombosis in COVID-19, as well as novel approaches for thrombosis prevention.

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