Distribution of α-actinin-3 Rs1815739 and Angiotensin-1 Converting Enzyme InDel Polymorphisms in Turkish Bodybuilders

Overview

Journal Biomed Rep

Specialty Biochemistry

Date 2020 Nov 5

PMID 33149911

Authors

Tolga Polat

Canan Sercan Dogan

Murat Dogan

Teoman Akcay

Korkut Ulucan

Affiliations

Soon will be listed here.

Abstract

The determination of the genetic profiles of successful athletes and the effects of these genetic parameters on athletic performance is gaining increasing interest. The majority of studies assessing the genetics of athletes usually analyse the most well-known genetic variations in athletes associated with the different specialties. The aim of the present study was to analyse the InDel and rs1815739 polymorphisms in Turkish bodybuilders. A total of 11 male bodybuilders were recruited and genotyped for these polymorphisms. The respective percentage of the II, ID and DD genotypes were 18, 73 and 9. For the genotype, the respective frequencies were 55 and 45 for the RX and RR genotypes. No XX genotype was detected. The allelic counts were 12 (55%) for I and 10 (45%) for the D alleles of ; and 12 (55%) and 10 (45%) for R and X alleles, respectively, for the genotype. Additionally, 5 athletes had ID + RX genotypes in terms of ACE InDel and ACTN3 rs1815739 polymorphisms, respectively. These results indicate the importance of endurance related alleles of and in bodybuilders. The results of the present are in agreement with previous studies, highlighting a potential association between specific polymorphisms and the endurance-related nature of bodybuilders. Further studies with larger cohorts are required to understand the association between these polymorphisms and specific parameters performance in bodybuilders.

References

Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F . An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990; 86(4):1343-6. PMC: 296868. DOI: 10.1172/JCI114844. View

Guth L, Roth S . Genetic influence on athletic performance. Curr Opin Pediatr. 2013; 25(6):653-8. PMC: 3993978. DOI: 10.1097/MOP.0b013e3283659087. View

Zhang Q, Cao Y, Chen J, Shen J, Ke D, Wang X . ACTN3 is associated with children's physical fitness in Han Chinese. Mol Genet Genomics. 2018; 294(1):47-56. DOI: 10.1007/s00438-018-1485-7. View

Ulucan K, Sercan C, Biyikli T . Distribution of Angiotensin-1 Converting Enzyme Insertion/Deletion and α-Actinin-3 Codon 577 Polymorphisms in Turkish Male Soccer Players. Genet Epigenet. 2015; 7:1-4. PMC: 4578552. DOI: 10.4137/GEG.S31479. View

Eroglu O, Zileli R, Nalbant M, Ulucan K . Prevalence of alpha actinin-3 gene (ACTN3) R577X and angiotensin converting enzyme (ACE) insertion / deletion gene polymorphisms in national and amateur Turkish athletes. Cell Mol Biol (Noisy-le-grand). 2018; 64(5):24-28. View

Roth S, Walsh S, Liu D, Metter E, Ferrucci L, Hurley B . The ACTN3 R577X nonsense allele is under-represented in elite-level strength athletes. Eur J Hum Genet. 2007; 16(3):391-4. PMC: 2668151. DOI: 10.1038/sj.ejhg.5201964. View

Guney A, Ergec D, Kirac D, Ozturhan H, Caner M, Koc G . Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease. Genet Mol Res. 2014; 12(4):6895-906. DOI: 10.4238/2013.December.19.8. View

Orysiak J, Mazur-Rozycka J, Busko K, Gajewski J, Szczepanska B, Malczewska-Lenczowska J . Individual and Combined Influence of ACE and ACTN3 Genes on Muscle Phenotypes in Polish Athletes. J Strength Cond Res. 2017; 32(10):2776-2782. DOI: 10.1519/JSC.0000000000001839. View

Egorova E, Borisova A, Mustafina L, Arkhipova A, Gabbasov R, Druzhevskaya A . The polygenic profile of Russian football players. J Sports Sci. 2014; 32(13):1286-93. DOI: 10.1080/02640414.2014.898853. View

10.

Helms E, Aragon A, Fitschen P . Evidence-based recommendations for natural bodybuilding contest preparation: nutrition and supplementation. J Int Soc Sports Nutr. 2014; 11:20. PMC: 4033492. DOI: 10.1186/1550-2783-11-20. View

11.

Puthucheary Z, Skipworth J, Rawal J, Loosemore M, van Someren K, Montgomery H . Genetic influences in sport and physical performance. Sports Med. 2011; 41(10):845-59. DOI: 10.2165/11593200-000000000-00000. View

12.

Montgomery H, Marshall R, Hemingway H, Myerson S, Clarkson P, Dollery C . Human gene for physical performance. Nature. 1998; 393(6682):221-2. DOI: 10.1038/30374. View

13.

Santiago C, Gonzalez-Freire M, Serratosa L, Morate F, Meyer T, Gomez-Gallego F . ACTN3 genotype in professional soccer players. Br J Sports Med. 2007; 42(1):71-3. DOI: 10.1136/bjsm.2007.039172. View

14.

Kikuchi N, Nakazato K . Effective utilization of genetic information for athletes and coaches: focus on ACTN3 R577X polymorphism. J Exerc Nutrition Biochem. 2015; 19(3):157-64. PMC: 4624116. DOI: 10.5717/jenb.2015.15093001. View

15.

Danser A, SCHALEKAMP M, Bax W, Van Den Brink A, Saxena P, Riegger G . Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation. 1995; 92(6):1387-8. DOI: 10.1161/01.cir.92.6.1387. View

16.

Corak A, Kapici S, Sercan C, Akkoc O, Ulucan K . A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes. Cell Mol Biol (Noisy-le-grand). 2017; 63(5):29-31. DOI: 10.14715/cmb/2017.63.5.6. View

17.

Ulucan K, Gole S, Altindas N, Guney A . Preliminary Findings of α -Actinin-3 Gene Distribution in Elite Turkish Wind Surfers. Balkan J Med Genet. 2013; 16(1):69-72. PMC: 3835299. DOI: 10.2478/bjmg-2013-0020. View

18.

Verdijk L, Jonkers R, Gleeson B, Beelen M, Meijer K, Savelberg H . Protein supplementation before and after exercise does not further augment skeletal muscle hypertrophy after resistance training in elderly men. Am J Clin Nutr. 2008; 89(2):608-16. DOI: 10.3945/ajcn.2008.26626. View