Variables Associated with Short-Term Weight Loss in a Cohort of Patients with Morbid Obesity According to Age and Three Types of Bariatric Surgery

Overview

Journal J Clin Med

Specialty General Medicine

Date 2020 Nov 5

PMID 33147793

Authors

Maria D Alvarez-Bermudez

Flores Martin-Reyes

Luis Ocana-Wilhelmi

Francisco J Moreno-Ruiz

Juan Alcaide Torres

Diego Fernandez-Garcia

Sergio Valdes

Noelia Moreno-Morales

Eduardo Garcia-Fuentes

Francisco J Tinahones

Lourdes Garrido-Sanchez

Affiliations

Soon will be listed here.

Abstract

The percentage of excess weight lost (%EWL) after bariatric surgery (BS) shows great discrepancies from one individual to another. To evaluate the %EWL one year after BS and to determine the existence of baseline biomarkers associated with weight loss. We studied 329 patients with morbid obesity undergoing three types of BS (biliopancreatic diversion (BPD), Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG)), depending on the %EWL one year after surgery: good responders (GR) (%EWL≥50%) and non-responders (NR) (%EWL <50%). The GR presented a higher percentage of change in anthropometric and biochemical variables compared to the NR group, even within each type of BS. There was a greater percentage of GR among those who underwent RYGB. The patients who underwent SG showed the lowest decrease in biochemical variables, both in GR and NR. Within the GR group, those with a lower age showed greater improvement compared to the other age groups. A %EWL ≥50% was negatively associated with the age and atherogenic index of plasma (AIP), and positively with the type of BS (RYGB). The GR group was associated with lower age and AIP and undergoing RYGB. Additionally, those patients who underwent SG showed a lower metabolic improvement.

References

Bhandari M, Reddy M, Kosta S, Mathur W, Fobi M . Laparoscopic sleeve gastrectomy versus laparoscopic gastric bypass: A retrospective cohort study. Int J Surg. 2019; 67:47-53. DOI: 10.1016/j.ijsu.2019.05.004. View

Campos G, Rabl C, Mulligan K, Posselt A, Rogers S, Westphalen A . Factors associated with weight loss after gastric bypass. Arch Surg. 2008; 143(9):877-883. PMC: 2747804. DOI: 10.1001/archsurg.143.9.877. View

Maclean L, Rhode B, Sampalis J, Forse R . Results of the surgical treatment of obesity. Am J Surg. 1993; 165(1):155-60; discussion 160-2. DOI: 10.1016/s0002-9610(05)80420-9. View

Reinhold R . Critical analysis of long term weight loss following gastric bypass. Surg Gynecol Obstet. 1982; 155(3):385-94. View

Khaitan L, Shea B . Laparoscopic vertical sleeve gastrectomy, long and short-term impact on weight loss and associated co-morbidities. Ann Transl Med. 2020; 8(Suppl 1):S5. PMC: 7154321. DOI: 10.21037/atm.2020.01.89. View

Sarzynski M, Jacobson P, Rankinen T, Carlsson B, Sjostrom L, Bouchard C . Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases. Int J Obes (Lond). 2010; 35(5):676-83. DOI: 10.1038/ijo.2010.166. View

Brethauer S, Kim J, El Chaar M, Papasavas P, Eisenberg D, Rogers A . Standardized outcomes reporting in metabolic and bariatric surgery. Obes Surg. 2015; 25(4):587-606. DOI: 10.1007/s11695-015-1645-3. View

Maggard M, Shugarman L, Suttorp M, Maglione M, Sugerman H, Sugarman H . Meta-analysis: surgical treatment of obesity. Ann Intern Med. 2005; 142(7):547-59. DOI: 10.7326/0003-4819-142-7-200504050-00013. View

Shen S, Lu Y, Li F, Yang C, Feng Y, Li H . Atherogenic index of plasma is an effective index for estimating abdominal obesity. Lipids Health Dis. 2018; 17(1):11. PMC: 5769292. DOI: 10.1186/s12944-018-0656-1. View

10.

Murri M, Garcia-Fuentes E, Garcia-Almeida J, Garrido-Sanchez L, Mayas M, Bernal R . Changes in oxidative stress and insulin resistance in morbidly obese patients after bariatric surgery. Obes Surg. 2010; 20(3):363-8. DOI: 10.1007/s11695-009-0021-6. View

11.

Nguyen N, Rivers R, Wolfe B . Factors associated with operative outcomes in laparoscopic gastric bypass. J Am Coll Surg. 2003; 197(4):548-55. DOI: 10.1016/S1072-7515(03)00648-3. View

12.

Sugerman H, Londrey G, KELLUM J, Wolf L, Liszka T, Engle K . Weight loss with vertical banded gastroplasty and Roux-Y gastric bypass for morbid obesity with selective versus random assignment. Am J Surg. 1989; 157(1):93-102. DOI: 10.1016/0002-9610(89)90427-3. View

13.

Ma Y, Pagoto S, Olendzki B, Hafner A, Perugini R, Mason R . Predictors of weight status following laparoscopic gastric bypass. Obes Surg. 2006; 16(9):1227-31. DOI: 10.1381/096089206778392284. View

14.

Lemieux I, Lamarche B, Couillard C, Pascot A, Cantin B, Bergeron J . Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study. Arch Intern Med. 2001; 161(22):2685-92. DOI: 10.1001/archinte.161.22.2685. View

15.

Still C, Wood G, Chu X, Manney C, Strodel W, Petrick A . Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery. Obesity (Silver Spring). 2013; 22(3):888-94. PMC: 3819407. DOI: 10.1002/oby.20529. View

16.

Sans A, Bailly L, Anty R, Sielezenef I, Gugenheim J, Tran A . Baseline Anthropometric and Metabolic Parameters Correlate with Weight Loss in Women 1-Year After Laparoscopic Roux-En-Y Gastric Bypass. Obes Surg. 2017; 27(11):2940-2949. DOI: 10.1007/s11695-017-2720-8. View

17.

Camastra S, Muscelli E, Gastaldelli A, Holst J, Astiarraga B, Baldi S . Long-term effects of bariatric surgery on meal disposal and β-cell function in diabetic and nondiabetic patients. Diabetes. 2013; 62(11):3709-17. PMC: 3806605. DOI: 10.2337/db13-0321. View

18.

Livingston E, Huerta S, Arthur D, Lee S, De Shields S, Heber D . Male gender is a predictor of morbidity and age a predictor of mortality for patients undergoing gastric bypass surgery. Ann Surg. 2002; 236(5):576-82. PMC: 1422615. DOI: 10.1097/00000658-200211000-00007. View

19.

Park C, Nam S, Choi H, Kim K, Kim D, Kim J . Comparative Efficacy of Bariatric Surgery in the Treatment of Morbid Obesity and Diabetes Mellitus: a Systematic Review and Network Meta-Analysis. Obes Surg. 2019; 29(7):2180-2190. DOI: 10.1007/s11695-019-03831-6. View

20.

Cottam D, Mattar S, Barinas-Mitchell E, Eid G, Kuller L, Kelley D . The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg. 2004; 14(5):589-600. DOI: 10.1381/096089204323093345. View