Microbiome in Cancer Progression and Therapy

Overview

Journal Curr Opin Microbiol

Specialty Microbiology

Date 2020 Nov 4

PMID 33147555

Citations 11

Authors

Natalia V Andreeva

Railia R Gabbasova

Sergei I Grivennikov

Affiliations

Soon will be listed here.

Abstract

A myriad of microbes living together with the host constitute microbiota, which possesses very diverse functions in regulation of host physiology. Recently, it has been unequivocally demonstrated that microbiota regulates cancer initiation, progression and responses to therapy. Here we review known pro-tumorigenic and anti-tumorigenic function of microbiota and mechanisms how microbes can regulate cancer cells and immune and stromal cells within the tumor microenvironment.

Citing Articles

Metagenomic and Transcriptomic Analysis Reveals Crosstalk Between Intratumor Mycobiome and Hosts in Early-Stage Nonsmoking Lung Adenocarcinoma Patients.

Sun Y, Gan Z, Liu S, Zhang S, Zhong W, Liu J Thorac Cancer. 2025; 16(2):e15527.

PMID: 39853685 PMC: 11756924. DOI: 10.1111/1759-7714.15527.

The emerging tumor microbe microenvironment: From delineation to multidisciplinary approach-based interventions.

Fu Y, Li J, Cai W, Huang Y, Liu X, Ma Z Acta Pharm Sin B. 2024; 14(4):1560-1591.

PMID: 38572104 PMC: 10985043. DOI: 10.1016/j.apsb.2023.11.018.

Gut microbiota and its therapeutic implications in tumor microenvironment interactions.

Feng P, Xue X, Bukhari I, Qiu C, Li Y, Zheng P Front Microbiol. 2024; 15:1287077.

PMID: 38322318 PMC: 10844568. DOI: 10.3389/fmicb.2024.1287077.

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications.

Zhao L, Mei J, Yu G, Lei L, Zhang W, Liu K Signal Transduct Target Ther. 2023; 8(1):201.

PMID: 37179402 PMC: 10183032. DOI: 10.1038/s41392-023-01406-7.

Gut Microbiome Composition and Its Metabolites Are a Key Regulating Factor for Malignant Transformation, Metastasis and Antitumor Immunity.

Lozenov S, Krastev B, Nikolaev G, Peshevska-Sekulovska M, Peruhova M, Velikova T Int J Mol Sci. 2023; 24(6).

PMID: 36983053 PMC: 10054493. DOI: 10.3390/ijms24065978.

References

Chittim C, Martinez Del Campo A, Balskus E . Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline. Nat Microbiol. 2018; 4(1):155-163. DOI: 10.1038/s41564-018-0294-4. View

Litvak Y, Mon K, Nguyen H, Chanthavixay G, Liou M, Velazquez E . Commensal Enterobacteriaceae Protect against Salmonella Colonization through Oxygen Competition. Cell Host Microbe. 2019; 25(1):128-139.e5. DOI: 10.1016/j.chom.2018.12.003. View

Tilg H, Adolph T, Gerner R, Moschen A . The Intestinal Microbiota in Colorectal Cancer. Cancer Cell. 2018; 33(6):954-964. DOI: 10.1016/j.ccell.2018.03.004. View

Merlos-Suarez A, Barriga F, Jung P, Iglesias M, Cespedes M, Rossell D . The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell. 2011; 8(5):511-24. DOI: 10.1016/j.stem.2011.02.020. View

Chung L, Thiele Orberg E, Geis A, Chan J, Fu K, DeStefano Shields C . Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells. Cell Host Microbe. 2018; 23(3):421. PMC: 6469393. DOI: 10.1016/j.chom.2018.02.004. View

Grivennikov S, Greten F, Karin M . Immunity, inflammation, and cancer. Cell. 2010; 140(6):883-99. PMC: 2866629. DOI: 10.1016/j.cell.2010.01.025. View

Iida N, Dzutsev A, Stewart C, Smith L, Bouladoux N, Weingarten R . Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science. 2013; 342(6161):967-70. PMC: 6709532. DOI: 10.1126/science.1240527. View

Pushalkar S, Hundeyin M, Daley D, Zambirinis C, Kurz E, Mishra A . The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression. Cancer Discov. 2018; 8(4):403-416. PMC: 6225783. DOI: 10.1158/2159-8290.CD-17-1134. View

Ma C, Han M, Heinrich B, Fu Q, Zhang Q, Sandhu M . Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science. 2018; 360(6391). PMC: 6407885. DOI: 10.1126/science.aan5931. View

10.

Wilson M, Jiang Y, Villalta P, Stornetta A, Boudreau P, Carra A . The human gut bacterial genotoxin colibactin alkylates DNA. Science. 2019; 363(6428). PMC: 6407708. DOI: 10.1126/science.aar7785. View

11.

Cardona F, Andres-Lacueva C, Tulipani S, Tinahones F, Queipo-Ortuno M . Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem. 2013; 24(8):1415-22. DOI: 10.1016/j.jnutbio.2013.05.001. View

12.

Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S . High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016; 531(7592):53-8. PMC: 4846772. DOI: 10.1038/nature17173. View

13.

Rogan M, Patterson L, Wang J, McBride J . Bacterial Manipulation of Wnt Signaling: A Host-Pathogen Tug-of-Wnt. Front Immunol. 2019; 10:2390. PMC: 6811524. DOI: 10.3389/fimmu.2019.02390. View

14.

Oskarsson T, Batlle E, Massague J . Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell. 2014; 14(3):306-21. PMC: 3998185. DOI: 10.1016/j.stem.2014.02.002. View

15.

Rubinstein M, Wang X, Liu W, Hao Y, Cai G, Han Y . Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin. Cell Host Microbe. 2013; 14(2):195-206. PMC: 3770529. DOI: 10.1016/j.chom.2013.07.012. View

16.

Qin Y, Roberts J, Grimm S, Lih F, Deterding L, Li R . An obesity-associated gut microbiome reprograms the intestinal epigenome and leads to altered colonic gene expression. Genome Biol. 2018; 19(1):7. PMC: 5782396. DOI: 10.1186/s13059-018-1389-1. View

17.

Boleij A, Hechenbleikner E, Goodwin A, Badani R, Stein E, Lazarev M . The Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients. Clin Infect Dis. 2014; 60(2):208-15. PMC: 4351371. DOI: 10.1093/cid/ciu787. View

18.

Hsu R, Chan C, Spicer J, Rousseau M, Giannias B, Rousseau S . LPS-induced TLR4 signaling in human colorectal cancer cells increases beta1 integrin-mediated cell adhesion and liver metastasis. Cancer Res. 2011; 71(5):1989-98. DOI: 10.1158/0008-5472.CAN-10-2833. View

19.

Sayin S, Wahlstrom A, Felin J, Jantti S, Marschall H, Bamberg K . Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 2013; 17(2):225-35. DOI: 10.1016/j.cmet.2013.01.003. View

20.

. The Integrative Human Microbiome Project. Nature. 2019; 569(7758):641-648. PMC: 6784865. DOI: 10.1038/s41586-019-1238-8. View