Impact of Osteopenia on Oncologic Outcomes After Curative Resection for Pancreatic Cancer

Overview

Journal In Vivo

Specialty Oncology

Date 2020 Nov 4

PMID 33144467

Citations 8

Authors

Takashi Motomura

Hideaki Uchiyama

Tomohiro Iguchi

Mizuki Ninomiya

Rintaro Yoshida

Takuya Honboh

Noriaki Sadanaga

Tetsuro Akashi

Hiroshi Matsuura

Affiliations

Soon will be listed here.

Abstract

Background/aim: We evaluated the relationship between low bone mineral density (BMD), also called osteopenia, and prognosis in patients who underwent resection for pancreatic cancer (PC).

Patients And Methods: We enrolled 91 consecutive patients who underwent curative resections for PC between May 2009 and January 2019. Their BMDs were measured at the Th11 vertebra using computed tomography. Patients were then divided by age-adjusted standard BMD values into the osteopenia group (n=34) and the non-osteopenia group (n=57). Their overall survival (OS) and recurrence-free survival (RFS) were compared (log-rank test).

Results: The two groups did not differ in age, BMI, tumor marker, operation time, blood loss, postoperative complications or stage. The osteopenia group had significantly worse 3-year rates for OS (46% vs. 30%, p=0.04) and RFS (41% vs. 26%, p=0.01). In multivariate analysis, osteopenia was an independent prognostic factor for RFS (HR=2.16, p=0.01).

Conclusion: Osteopenia is an adverse prognostic factor for patients with resected PC.

Citing Articles

Bone mineral density as a prognostic marker in patients with biliary tract cancer undergoing surgery.

Heinrichs L, Fluegen G, Loosen S, Loberg C, Wittig L, Quaas A BJC Rep. 2024; 2(1):72.

PMID: 39323978 PMC: 11420066. DOI: 10.1038/s44276-024-00094-2.

Impact of osteopenia and osteosarcopenia on the outcomes after surgery of hepatobiliary-pancreatic cancers.

Wang X, Wu M, Liu Q, He W, Tian Y, Zhang Y Front Oncol. 2024; 14:1403822.

PMID: 39099698 PMC: 11294096. DOI: 10.3389/fonc.2024.1403822.

Preoperative Bone Loss Predicts Decreased Survival Associated with Microvascular Invasion after Resection of Hepatocellular Carcinoma.

Ishida T, Miki A, Sakuma Y, Watanabe J, Endo K, Sasanuma H Cancers (Basel). 2024; 16(11).

PMID: 38893206 PMC: 11171155. DOI: 10.3390/cancers16112087.

Osteosarcopenia: the coexistence of sarcopenia and osteopenia is predictive of prognosis and postoperative complications after curative resection for colorectal cancer.

Fujimoto T, Tamura K, Nagayoshi K, Mizuuchi Y, Oh Y, Nara T Surg Today. 2024; 55(1):78-89.

PMID: 38880803 DOI: 10.1007/s00595-024-02883-1.

Preoperative Osteopenia as Risk Factor for Death from Other Diseases After Gastrectomy in Elderly Patients.

Shimizu S, Matsunaga T, Sakano Y, Makinoya M, Shishido Y, Miyatani K In Vivo. 2023; 37(6):2662-2668.

PMID: 37905614 PMC: 10621444. DOI: 10.21873/invivo.13375.

References

Yamada D, Eguchi H, Iwagami Y, Mukai Y, Hashimoto Y, Asaoka T . Patients Treated with Preoperative Chemoradiation for Pancreatic Ductal Adenocarcinoma have Impaired Bone Density, a Predictor of Distant Metastasis. Ann Surg Oncol. 2017; 24(12):3715-3724. DOI: 10.1245/s10434-017-6040-y. View

Peng P, Hyder O, Firoozmand A, Kneuertz P, Schulick R, Huang D . Impact of sarcopenia on outcomes following resection of pancreatic adenocarcinoma. J Gastrointest Surg. 2012; 16(8):1478-86. PMC: 3578313. DOI: 10.1007/s11605-012-1923-5. View

Toshima T, Yoshizumi T, Ikegami T, Harada N, Itoh S, Mano Y . Impact of Osteopenia in Liver Cirrhosis: Special Reference to Standard Bone Mineral Density with Age. Anticancer Res. 2018; 38(11):6465-6471. DOI: 10.21873/anticanres.13009. View

Furukawa K, Uwagawa T, Haruki K, Fujiwara Y, Iida T, Shiba H . Nuclear factor κB activity correlates with the progression and prognosis of pancreatic cancer in a mouse model. Surg Today. 2012; 43(2):171-7. DOI: 10.1007/s00595-012-0279-5. View

Sharma P, Parikh N, Yu J, Barman P, Derstine B, Sonnenday C . Bone mineral density predicts posttransplant survival among hepatocellular carcinoma liver transplant recipients. Liver Transpl. 2016; 22(8):1092-8. PMC: 4961525. DOI: 10.1002/lt.24458. View

Sclabas G, Fujioka S, Schmidt C, Evans D, Chiao P . NF-kappaB in pancreatic cancer. Int J Gastrointest Cancer. 2003; 33(1):15-26. DOI: 10.1385/IJGC:33:1:15. View

Ma Y, Zhang P, Wang F, Yang J, Liu Z, Qin H . Association between vitamin D and risk of colorectal cancer: a systematic review of prospective studies. J Clin Oncol. 2011; 29(28):3775-82. DOI: 10.1200/JCO.2011.35.7566. View

Siegel R, Miller K, Jemal A . Cancer statistics, 2018. CA Cancer J Clin. 2018; 68(1):7-30. DOI: 10.3322/caac.21442. View

Srikoon P, Kariya R, Kudo E, Goto H, Vaeteewoottacharn K, Taura M . Diethyldithiocarbamate suppresses an NF-kappaB dependent metastatic pathway in cholangiocarcinoma cells. Asian Pac J Cancer Prev. 2013; 14(7):4441-6. DOI: 10.7314/apjcp.2013.14.7.4441. View

10.

Abe T, Nakata K, Kibe S, Mori Y, Miyasaka Y, Ohuchida K . Prognostic Value of Preoperative Nutritional and Immunological Factors in Patients with Pancreatic Ductal Adenocarcinoma. Ann Surg Oncol. 2018; 25(13):3996-4003. DOI: 10.1245/s10434-018-6761-6. View

11.

Tsujita E, Ikeda Y, Kinjo N, Yamashita Y, Hisano T, Furukawa M . Postoperative Neutrophil-to-Lymphocyte Ratio as a Predictor of Long-Term Prognosis after Pancreatectomy for Pancreatic Carcinoma: A Retrospective Analysis. Am Surg. 2017; 83(6):610-616. View

12.

Harimoto N, Yoshizumi T, Inokuchi S, Itoh S, Adachi E, Ikeda Y . Prognostic Significance of Preoperative Controlling Nutritional Status (CONUT) Score in Patients Undergoing Hepatic Resection for Hepatocellular Carcinoma: A Multi-institutional Study. Ann Surg Oncol. 2018; 25(11):3316-3323. DOI: 10.1245/s10434-018-6672-6. View

13.

Reid I, Horne A, Mihov B, Stewart A, Garratt E, Wong S . Fracture Prevention with Zoledronate in Older Women with Osteopenia. N Engl J Med. 2018; 379(25):2407-2416. DOI: 10.1056/NEJMoa1808082. View

14.

Li C, Yu K, Shyh-Chang N, Li G, Jiang L, Yu S . Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention. J Cachexia Sarcopenia Muscle. 2019; 10(3):586-600. PMC: 6596393. DOI: 10.1002/jcsm.12417. View

15.

Gnant M, Mlineritsch B, Stoeger H, Luschin-Ebengreuth G, Heck D, Menzel C . Adjuvant endocrine therapy plus zoledronic acid in premenopausal women with early-stage breast cancer: 62-month follow-up from the ABCSG-12 randomised trial. Lancet Oncol. 2011; 12(7):631-41. DOI: 10.1016/S1470-2045(11)70122-X. View

16.

Harimoto N, Shirabe K, Yamashita Y, Ikegami T, Yoshizumi T, Soejima Y . Sarcopenia as a predictor of prognosis in patients following hepatectomy for hepatocellular carcinoma. Br J Surg. 2013; 100(11):1523-30. DOI: 10.1002/bjs.9258. View

17.

Fedirko V, Duarte-Salles T, Bamia C, Trichopoulou A, Aleksandrova K, Trichopoulos D . Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case-control study. Hepatology. 2014; 60(4):1222-30. DOI: 10.1002/hep.27079. View

18.

Yao S, Kaido T, Okumura S, Iwamura S, Miyachi Y, Shirai H . Bone mineral density correlates with survival after resection of extrahepatic biliary malignancies. Clin Nutr. 2019; 38(6):2770-2777. DOI: 10.1016/j.clnu.2018.12.004. View

19.

Khalili M, Morano W, Marconcini L, Shaikh M, Gleeson E, Styler M . Multidisciplinary strategies in bloodless medicine and surgery for patients undergoing pancreatectomy. J Surg Res. 2018; 229:208-215. DOI: 10.1016/j.jss.2018.04.009. View

20.

Motomura T, Shirabe K, Mano Y, Muto J, Toshima T, Umemoto Y . Neutrophil-lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol. 2012; 58(1):58-64. DOI: 10.1016/j.jhep.2012.08.017. View