Treatment Outcome of the Combination Therapy of High-dose Rate Intracavitary Brachytherapy and Intensity-modulated Radiation Therapy With Central-shielding for Cervical Cancer

Overview

Journal In Vivo

Specialty Oncology

Date 2020 Nov 4

PMID 33144446

Citations 3

Authors

Yuki Mukai

Yumiko Minagawa

Hiromi Inoue

Akiko Sato

Kengo Matsui

Takanori Fukuda

Kazuya Onuma

Hideyuki Hongo

Ryosuke Shirata

Hironori Nagata

Harumitu Hashimoto

Tomio Inoue

Masaharu Hata

Motoko Omura

Affiliations

Soon will be listed here.

Abstract

Background/aim: This study aimed to evaluate the clinical outcome of intensity-modulated radiation therapy (IMRT) and high-dose-rate intracavitary brachytherapy (HDR-ICBT) in uterine cervical cancer (UCC). IMRT consisted of whole-pelvic radiation therapy (WPRT) and sequential WPRT with central-shielding (WPRT-CS).

Patients And Methods: Thirty UCC patients treated with IMRT using TomoTherapy, were retrospectively analyzed.

Results: The median dose of WPRT and WPRT-CS was 36 and 14.4 Gy and the median total dose of these was 50 Gy in 25 fractions (Fr). Median HDR-ICBT dose/Fr to Point A was 25 Gy/5 Fr. Median 2 Gy per fraction-equivalent dose (EQD2) of combined WPRT and HDR-ICBT to Point A (α/β=10) was 71.0 Gy. The 3-year local control, disease-free survival, and overall survival rates were 89.9%, 83.3%, and 86.3%.

Conclusion: IMRT of WPRT and WPRT-CS given in combination with HDR-ICBT was a feasible therapy resulting in good disease control and tolerance in patients with UCC.

Citing Articles

Observation of hemostatic effectiveness and safety of ultrasound-CT guided 3D intracavitary and interstitial brachytherapy in the treatment of larger cervical cancer with bleeding: A retrospective study.

Hu Y, Jin Y, Wang D, Luo Y Medicine (Baltimore). 2023; 102(37):e34904.

PMID: 37713892 PMC: 10508520. DOI: 10.1097/MD.0000000000034904.

Intensity-modulated radiation therapy with the central shielding technique for patients with uterine cervical cancer†.

Torii A, Tomita N, Kuno M, Nishio M, Yamada Y, Takaoka T J Radiat Res. 2023; 64(4):720-727.

PMID: 37321676 PMC: 10354837. DOI: 10.1093/jrr/rrad039.

Clinical Outcomes and Toxicity of CT-guided High Dose-rate Brachytherapy in Women With Locally-advanced Cervical Cancer.

De Sanctis V, Facondo G, Vullo G, Anzellini D, Sanguineti G, Nardangeli A Cancer Diagn Progn. 2023; 3(2):194-200.

PMID: 36875316 PMC: 9949546. DOI: 10.21873/cdp.10201.

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