[Magnesium: Relevance for General Practitioners - a Position Paper Of the Society for Magnesium Research E. V.]

Overview

Journal Dtsch Med Wochenschr

Date 2020 Nov 3

PMID 33142330

Authors

Oliver Micke

Jurgen Vormann

Hans-Georg Classen

Klaus Kisters

Affiliations

Soon will be listed here.

Abstract

Magnesium deficiency is to be expected in the population and particularly among risk groups. Magnesium deficiency can cause numerous symptoms, is per se pathological and thus requires treatment. Diagnostics is based on clinical symptoms in conjunction with anamnestic criteria and laboratory parameters. Insufficient magnesium supply is associated with an increased risk for many diseases, e. g. metabolic syndrome, type 2 diabetes and cardiovascular diseases. Magnesium deficiency often appears as comorbidity and may exacerbate diseases. Physicians should pay more attention to magnesium in order to avoid deficits as a cause for multiple symptoms and risk factor for diseases. Optimisation of magnesium status may make an important contribution to the prevention of diseases. Oral magnesium therapy is safe and cost effective.

References

Mofrad M, Djafarian K, Mozaffari H, Shab-Bidar S . Effect of magnesium supplementation on endothelial function: A systematic review and meta-analysis of randomized controlled trials. Atherosclerosis. 2018; 273:98-105. DOI: 10.1016/j.atherosclerosis.2018.04.020. View

Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A . Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis. QJM. 2016; 109(7):453-459. DOI: 10.1093/qjmed/hcw048. View

de Baaij J, Hoenderop J, Bindels R . Magnesium in man: implications for health and disease. Physiol Rev. 2014; 95(1):1-46. DOI: 10.1152/physrev.00012.2014. View

Cunha A, dEl-Rei J, Medeiros F, Umbelino B, Oigman W, Touyz R . Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. J Hypertens. 2016; 35(1):89-97. DOI: 10.1097/HJH.0000000000001129. View

Veronese N, Watutantrige-Fernando S, Luchini C, Solmi M, Sartore G, Sergi G . Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials. Eur J Clin Nutr. 2016; 70(12):1354-1359. DOI: 10.1038/ejcn.2016.154. View

Rosanoff A, Weaver C, Rude R . Suboptimal magnesium status in the United States: are the health consequences underestimated?. Nutr Rev. 2012; 70(3):153-64. DOI: 10.1111/j.1753-4887.2011.00465.x. View

Schimatschek H, Rempis R . Prevalence of hypomagnesemia in an unselected German population of 16,000 individuals. Magnes Res. 2002; 14(4):283-90. View

Mauskop A, Varughese J . Why all migraine patients should be treated with magnesium. J Neural Transm (Vienna). 2012; 119(5):575-9. DOI: 10.1007/s00702-012-0790-2. View

Worwag M, Classen H, Schumacher E . Prevalence of magnesium and zinc deficiencies in nursing home residents in Germany. Magnes Res. 1999; 12(3):181-9. View

10.

Spatling L, Classen H, Kulpmann W, Manz F, Rob P, Schimatschek H . [Diagnosing magnesium deficiency. Current recommendations of the Society for Magnesium Research]. Fortschr Med Orig. 2005; 118 Suppl 2:49-53. View

11.

Iezhitsa I . Potassium and magnesium depletions in congestive heart failure--pathophysiology, consequences and replenishment. Clin Calcium. 2005; 15(11):123-33. DOI: CliCa051118851895. View

12.

Vierling W, Liebscher D, Micke O, von Ehrlich B, Kisters K . [Magnesium deficiency and therapy in cardiac arrhythmias: recommendations of the German Society for Magnesium Research]. Dtsch Med Wochenschr. 2013; 138(22):1165-71. DOI: 10.1055/s-0033-1343206. View

13.

Xiong J, He T, Wang M, Nie L, Zhang Y, Wang Y . Serum magnesium, mortality, and cardiovascular disease in chronic kidney disease and end-stage renal disease patients: a systematic review and meta-analysis. J Nephrol. 2019; 32(5):791-802. DOI: 10.1007/s40620-019-00601-6. View

14.

Branea I, Gaita D, Dragulescu I, Socoteanu I, Luca C, Mancas S . Assessment of treatment with orotate magnesium in early postoperative period of patients with cardiac insufficiency and coronary artery by-pass grafts (ATOMIC). Rom J Intern Med. 2004; 37(3):287-96. View

15.

Picardi S, Lirk P, Blobner M, Schonherr M, Hollmann M . [Adjuvants in modern anesthesia - magnesium]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2015; 50(6):380-7. DOI: 10.1055/s-0041-102214. View

16.

Joris P, Plat J, Bakker S, Mensink R . Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial. Am J Clin Nutr. 2016; 103(5):1260-6. DOI: 10.3945/ajcn.116.131466. View

17.

Elin R . Assessment of magnesium status for diagnosis and therapy. Magnes Res. 2010; 23(4):S194-8. DOI: 10.1684/mrh.2010.0213. View

18.

Ismail Y, Ismail A, Ismail A . The underestimated problem of using serum magnesium measurements to exclude magnesium deficiency in adults; a health warning is needed for "normal" results. Clin Chem Lab Med. 2010; 48(3):323-7. DOI: 10.1515/CCLM.2010.077. View

19.

DiNicolantonio J, Liu J, OKeefe J . Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018; 5(2):e000775. PMC: 6045762. DOI: 10.1136/openhrt-2018-000775. View

20.

Adamopoulos C, Pitt B, Sui X, Love T, Zannad F, Ahmed A . Low serum magnesium and cardiovascular mortality in chronic heart failure: a propensity-matched study. Int J Cardiol. 2008; 136(3):270-7. PMC: 2721016. DOI: 10.1016/j.ijcard.2008.05.006. View