Regulation of Peroxisomal Trafficking and Distribution

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2020 Nov 3

PMID 33141311

Citations 7

Authors

Christian Covill-Cooke

Viktoriya S Toncheva

Josef T Kittler

Affiliations

Soon will be listed here.

Abstract

Peroxisomes are organelles that perform a wide range of essential metabolic processes. To ensure that peroxisomes are optimally positioned in the cell, they must be transported by both long- and short-range trafficking events in response to cellular needs. Here, we review our current understanding of the mechanisms by which the cytoskeleton and organelle contact sites alter peroxisomal distribution. Though the focus of the review is peroxisomal transport in mammalian cells, findings from flies and fungi are used for comparison and to inform the gaps in our understanding. Attention is given to the apparent overlap in regulatory mechanisms for mitochondrial and peroxisomal trafficking, along with the recently discovered role of the mitochondrial Rho-GTPases, Miro, in peroxisomal dynamics. Moreover, we outline and discuss the known pathological and pharmacological conditions that perturb peroxisomal positioning. We conclude by highlighting several gaps in our current knowledge and suggest future directions that require attention.

Citing Articles

Miro GTPases at the Crossroads of Cytoskeletal Dynamics and Mitochondrial Trafficking.

Aspenstrom P Cells. 2024; 13(7.

PMID: 38607086 PMC: 11012113. DOI: 10.3390/cells13070647.

The peroxisome: an update on mysteries 3.0.

Kumar R, Islinger M, Worthy H, Carmichael R, Schrader M Histochem Cell Biol. 2024; 161(2):99-132.

PMID: 38244103 PMC: 10822820. DOI: 10.1007/s00418-023-02259-5.

Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains.

Semikasev E, Ahlemeyer B, Acker T, Schanzer A, Baumgart-Vogt E Acta Neuropathol Commun. 2023; 11(1):80.

PMID: 37170361 PMC: 10176950. DOI: 10.1186/s40478-023-01567-0.

Fission Impossible (?)-New Insights into Disorders of Peroxisome Dynamics.

Carmichael R, Islinger M, Schrader M Cells. 2022; 11(12).

PMID: 35741050 PMC: 9221819. DOI: 10.3390/cells11121922.

Insights Into the Peroxisomal Protein Inventory of Zebrafish.

Kamoshita M, Kumar R, Anteghini M, Kunze M, Islinger M, Martins Dos Santos V Front Physiol. 2022; 13:822509.

PMID: 35295584 PMC: 8919083. DOI: 10.3389/fphys.2022.822509.

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