Disseminated Pelvic Actinomycosis Caused by

Overview

Journal Antibiotics (Basel)

Specialty Pharmacology

Date 2020 Nov 3

PMID 33137889

Citations 3

Authors

Olga Dzupova

Jana Kulichova

Jiri Benes

Affiliations

Soon will be listed here.

Abstract

Actinomycosis is a chronic bacterial infection characterized by continuous local spread, irrespective of anatomical barriers, and granulomatous suppurative inflammation. Due to its expansive local growth, it can simulate a malignant tumour. Subsequent hematogenous dissemination to distant organs can mimic metastases and further increase suspicion for malignancy. A case of severe disseminated pelvic actinomycosis associated with intrauterine device is described here. The patient presented with a pelvic mass mimicking a tumour, bilateral ureteral obstruction, ascites, multinodular involvement of the liver, lungs and spleen, inferior vena cava thrombosis and extreme cachexia. Actinomycosis was diagnosed by liver biopsy and confirmed by culture of from extracted intrauterine contraceptive device (IUD). Prolonged treatment with aminopenicillin and surgery resulted in recovery with moderate sequelae.

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References

Thompson L, LOVESTEDT S . An Actinomyces-like organism obtained from the human mouth. Proc Staff Meet Mayo Clin. 1951; 26(10):169-75. View

Garcia-Garcia A, Ramirez-Duran N, Sandoval-Trujillo H, Romero-Figueroa M . Pelvic Actinomycosis. Can J Infect Dis Med Microbiol. 2017; 2017:9428650. PMC: 5480022. DOI: 10.1155/2017/9428650. View

Bonnez W, Lattimer G, Mohanraj N, Johnson T . Actinomyces naeslundii as an agent of pelvic actinomycosis in the presence of an intrauterine device. J Clin Microbiol. 1985; 21(2):273-5. PMC: 271633. DOI: 10.1128/jcm.21.2.273-275.1985. View

Curtis E, Pine L . Actinomyces in the vaginas of women with and without intrauterine contraceptive devices. Am J Obstet Gynecol. 1981; 140(8):880-4. DOI: 10.1016/0002-9378(81)90078-8. View

Galata C, Vogelmann R, Gaiser T, Post S, Horisberger K . Abdominopelvic actinomycosis in three different locations with invasion of the abdominal wall and ureteric obstruction: An uncommon presentation. Int J Surg Case Rep. 2015; 12:48-51. PMC: 4486104. DOI: 10.1016/j.ijscr.2015.05.016. View

Sehnal B, Benes J, Kolarova Z, Mojhova M, Zikan M . Pelvic actinomycosis and IUD. Ceska Gynekol. 2019; 83(5):386-390. View

Park H, Park K, Kim S, Sung H, Choi S, Kim Y . A Case of Disseminated Infection due to Actinomyces meyeri Involving Lung and Brain. Infect Chemother. 2015; 46(4):269-73. PMC: 4285003. DOI: 10.3947/ic.2014.46.4.269. View

Yang S, Im Y . Severe abdominopelvic actinomycosis with colon perforation and hepatic involvement mimicking advanced sigmoid colon cancer with hepatic metastasis: a case study. BMC Surg. 2018; 18(1):51. PMC: 6090905. DOI: 10.1186/s12893-018-0386-3. View

Westhoff C . IUDs and colonization or infection with Actinomyces. Contraception. 2007; 75(6 Suppl):S48-50. DOI: 10.1016/j.contraception.2007.01.006. View

10.

Kononen E, Wade W . Actinomyces and related organisms in human infections. Clin Microbiol Rev. 2015; 28(2):419-42. PMC: 4402957. DOI: 10.1128/CMR.00100-14. View

11.

Coleman R, GEORG L, Rozzell A . Actinomyces naeslundii as an agent of human actinomycosis. Appl Microbiol. 1969; 18(3):420-6. PMC: 377997. DOI: 10.1128/am.18.3.420-426.1969. View

12.

Chinnakkulam Kandhasamy S, Rajendar B, Sahoo A, Ganesh R, Goneppanavar M, Nelamangala Ramakrishnaiah V . Rare Abdominopelvic Actinomycosis Causing an Intestinal Band Obstruction and Mimicking an Ovarian Malignancy. Cureus. 2018; 10(5):e2721. PMC: 6067810. DOI: 10.7759/cureus.2721. View

13.

Choi M, Baek J, Beak J, Lee J, Park S, Lee W . Clinical features of abdominopelvic actinomycosis: report of twenty cases and literature review. Yonsei Med J. 2009; 50(4):555-9. PMC: 2730619. DOI: 10.3349/ymj.2009.50.4.555. View

14.

Li J, Helmerhorst E, Leone C, Troxler R, Yaskell T, Haffajee A . Identification of early microbial colonizers in human dental biofilm. J Appl Microbiol. 2004; 97(6):1311-8. DOI: 10.1111/j.1365-2672.2004.02420.x. View

15.

HOWELL Jr A, MURPHY 3rd W, Paul F, STEPHAN R . Oral strains of Actinomyces. J Bacteriol. 1959; 78(1):82-95. PMC: 290487. DOI: 10.1128/jb.78.1.82-95.1959. View

16.

Fazili T, Blair D, Riddell S, Kiska D, Nagra S . Actinomyces meyeri infection: case report and review of the literature. J Infect. 2012; 65(4):357-61. DOI: 10.1016/j.jinf.2012.02.016. View

17.

Taga S . Diagnosis and therapy of pelvic actinomycosis. J Obstet Gynaecol Res. 2007; 33(6):882-5. DOI: 10.1111/j.1447-0756.2007.00673.x. View

18.

Henssge U, Do T, Radford D, Gilbert S, Clark D, Beighton D . Emended description of Actinomyces naeslundii and descriptions of Actinomyces oris sp. nov. and Actinomyces johnsonii sp. nov., previously identified as Actinomyces naeslundii genospecies 1, 2 and WVA 963. Int J Syst Evol Microbiol. 2009; 59(Pt 3):509-16. PMC: 2884933. DOI: 10.1099/ijs.0.000950-0. View

19.

Ellen R, Banting D, Fillery E . Longitudinal microbiological investigation of a hospitalized population of older adults with a high root surface caries risk. J Dent Res. 1985; 64(12):1377-81. DOI: 10.1177/00220345850640121001. View

20.

Triantopoulou C, van der Molen A, Van Es A, Giannila M . Abdominopelvic actinomycosis: spectrum of imaging findings and common mimickers. Acta Radiol Short Rep. 2014; 3(2):2047981614524570. PMC: 4001438. DOI: 10.1177/2047981614524570. View