The Y Chromosome: A Complex Locus for Genetic Analyses of Complex Human Traits

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2020 Nov 3

PMID 33137877

Citations 11

Authors

Katherine Parker

A Mesut Erzurumluoglu

Santiago Rodriguez

Affiliations

Soon will be listed here.

Abstract

The Human Y chromosome (ChrY) has been demonstrated to be a powerful tool for phylogenetics, population genetics, genetic genealogy and forensics. However, the importance of ChrY genetic variation in relation to human complex traits is less clear. In this review, we summarise existing evidence about the inherent complexities of ChrY variation and their use in association studies of human complex traits. We present and discuss the specific particularities of ChrY genetic variation, including Y chromosomal haplogroups, that need to be considered in the design and interpretation of genetic epidemiological studies involving ChrY.

Citing Articles

The effects of loss of Y chromosome on male health.

Bruhn-Olszewska B, Markljung E, Rychlicka-Buniowska E, Sarkisyan D, Filipowicz N, Dumanski J Nat Rev Genet. 2025; .

PMID: 39743536 DOI: 10.1038/s41576-024-00805-y.

Biological sex affects functional variation across the human genome.

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Leveraging sex-genetic interactions to understand brain disorders: recent advances and current gaps.

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Mitochondrial DNA: Inherent Complexities Relevant to Genetic Analyses.

Ferreira T, Rodriguez S Genes (Basel). 2024; 15(5).

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Chromosome-Y haplogroups in Asturias (Northern Spain) and their association with severe COVID-19.

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