Modeling Cancer Progression Using Human Pluripotent Stem Cell-derived Cells and Organoids

Overview

Journal Stem Cell Res

Publisher Elsevier

Specialty Cell Biology

Date 2020 Nov 2

PMID 33137568

Citations 8

Authors

Meili Zhang

J Jeya Vandana

Lauretta Lacko

Shuibing Chen

Affiliations

Soon will be listed here.

Abstract

Conventional cancer cell lines and animal models have been mainstays of cancer research. More recently, human pluripotent stem cells (hPSCs) and hPSC-derived organoid technologies, together with genome engineering approaches, have provided a complementary platform to model cancer progression. Here, we review the application of these technologies in cancer modeling with respect to the cell-of-origin, cancer propagation, and metastasis. We further discuss the benefits and challenges accompanying the use of hPSC models for cancer research and discuss their broad applicability in drug discovery, biomarker identification, decoding molecular mechanisms, and the deconstruction of clonal and intra-tumoral heterogeneity. In summary, hPSC-derived organoids provide powerful models to recapitulate the pathogenic states in cancer and to perform drug discovery.

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