CrAssphage Genomes Identified in Fecal Samples of an Adult and Infants with Evidence of Positive Genomic Selective Pressure Within Tail Protein Genes

Overview

Journal Virus Res

Specialty Microbiology

Date 2020 Nov 2

PMID 33137401

Citations 8

Authors

Bryan P Brown

Denis Chopera

Enock Havyarimana

Jerome Wendoh

Shameem Jaumdally

Donald D Nyangahu

Clive M Gray

Darren P Martin

Arvind Varsani

Heather B Jaspan

Affiliations

Soon will be listed here.

Abstract

crAssphages are a broad group of diverse bacteriophages in the order Caudovirales that have been found to be highly abundant in the human gastrointestinal tract. Despite their high prevalence, we have an incomplete understanding of how crAssphages shape and respond to ecological and evolutionary dynamics in the gut. Here, we report genomes of crAssphages from feces of one South African woman and three infants. Across the complete genome sequences of the South African crAssphages described here, we identify particularly elevated positive selection in RNA polymerase and phage tail protein encoding genes, contrasted against purifying selection, genome-wide. We further validate these findings against a crAssphage genome from previous studies. Together, our results suggest hotspots of selection within crAssphage RNA polymerase and phage tail protein encoding genes are potentially mediated by interactions between crAssphages and their bacterial partners.

Citing Articles

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