Modulating Microenvironments for Treating Glioblastoma

Overview

Journal Curr Tissue Microenviron Rep

Specialty Cell Biology

Date 2020 Nov 2

PMID 33134977

Citations 4

Authors

LaDeidra Monet Roberts

Jennifer Munson

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: This review focuses on the development and progression of glioblastoma through the brain and glioma microenvironment. Specifically we highlight how the tumor microenvironment contributes to the hallmarks of cancer in hopes of offering novel therapeutic options and tools to target this microenvironment.

Recent Findings: The hallmarks of cancer, which represent elements of cancers that contribute to the disease's malignancy, yet elements within the brain tumor microenvironment, such as other cellular types as well as biochemical and biophysical cues that can each uniquely affect tumor cells, have not been well-described in this context and serve as potential targets for modulation.

Summary: Here, we highlight how the brain tumor microenvironment contributes to the progression and therapeutic response of tumor cells. Specifically, we examine these contributions through the lens of Hanahan & Weinberg's Hallmarks of Cancer in order to identify potential novel targets within the brain that may offer a means to treat brain cancers, including the deadliest brain cancer, glioblastoma.

Citing Articles

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Investigating the Interactions of Glioma Stem Cells in the Perivascular Niche at Single-Cell Resolution using a Microfluidic Tumor Microenvironment Model.

Adjei-Sowah E, OConnor S, Veldhuizen J, Lo Cascio C, Plaisier C, Mehta S Adv Sci (Weinh). 2022; 9(21):e2201436.

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Engineering in vitro immune-competent tissue models for testing and evaluation of therapeutics.

Hammel J, Zatorski J, Cook S, Pompano R, Munson J Adv Drug Deliv Rev. 2022; 182:114111.

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SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation.

Stevanovic M, Kovacevic-Grujicic N, Mojsin M, Milivojevic M, Drakulic D World J Stem Cells. 2021; 13(10):1417-1445.

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Glioma Pericytes Promote Angiogenesis by Producing Periostin.

Bernardes S, Cunha Xavier Pinto M, Amorim J, Azevedo V, Resende R, Mintz A Cell Mol Neurobiol. 2020; 42(3):557-564.

PMID: 33010018 PMC: 8018985. DOI: 10.1007/s10571-020-00975-3.

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