Association of Vitamin D and Knee Osteoarthritis in Younger Individuals

Overview

Journal World J Orthop

Publisher Baishideng Publishing Group

Specialty Orthopedics

Date 2020 Nov 2

PMID 33134104

Citations 10

Authors

Sujit Kumar Tripathy

Amrit Gantaguru

Saurav Narayan Nanda

Sandeep Velagada

Anand Srinivasan

Manaswini Mangaraj

Affiliations

Soon will be listed here.

Abstract

Background: The incidence of primary osteoarthritis knee is gradually increasing among young individuals. The increasing prevalence of obesity, sedentary lifestyle, sporting activity, and vitamin D deficiency (VDD) has been hypothesized for this shifting disease trend. This study was designed to look for the association of serum vitamin D among these young arthritic patients.

Aim: To look for the association of serum vitamin D in younger knee osteoarthritis (KOA) patients.

Methods: In a 2-year observational study, 146 non-obese KOA patients of 35-60 years were evaluated clinically (Knee injury and Osteoarthritis Outcome Score, KOOS) and radiologically (Kellegren-Lawrence stage, KL). The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated.

Results: Both the groups were comparable in terms of age and sex. The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL, respectively ( < 0.001). Inadequate serum 25(OH)D level (< 30 ng/mL) was found in 46.57% of KOA patients and 24% of normal healthy participants indicating a significant positive association (odds ratio 2.77, 95%CI: 1.67-4.54, < 0.001). The 25(OH)D level in KL grade I, II, III and IV was 43.40, 30.59, 31.56 and 33.93 ng/mL respectively (no difference, = 0.47). Similarly, the KOOS score in sufficient, insufficient and deficient groups were 65.31, 60.36 and 65.31, respectively (no difference, = 0.051).

Conclusion: The serum 25(OH)D level is significantly low in younger KOA patients. However, the clinical and radiological severities have no association with serum vitamin D level.

Citing Articles

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Annamalai R, Sujhithra A, Danis Vijay D J Clin Orthop Trauma. 2023; 46:102278.

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The association of vitamin D status with oxidative stress biomarkers and matrix metalloproteinases in patients with knee osteoarthritis.

Amirkhizi F, Ghoreishy S, Baker E, Hamedi-Shahraki S, Asghari S Front Nutr. 2023; 10:1101516.

PMID: 36845046 PMC: 9944738. DOI: 10.3389/fnut.2023.1101516.

References

Konstari S, Paananen M, Heliovaara M, Knekt P, Marniemi J, Impivaara O . Association of 25-hydroxyvitamin D with the incidence of knee and hip osteoarthritis: a 22-year follow-up study. Scand J Rheumatol. 2011; 41(2):124-31. DOI: 10.3109/03009742.2011.617314. View

Glover T, Goodin B, Horgas A, Kindler L, King C, Sibille K . Vitamin D, race, and experimental pain sensitivity in older adults with knee osteoarthritis. Arthritis Rheum. 2012; 64(12):3926-35. PMC: 3510313. DOI: 10.1002/art.37687. View

Goswami R, Mishra S, Kochupillai N . Prevalence & potential significance of vitamin D deficiency in Asian Indians. Indian J Med Res. 2008; 127(3):229-38. View

Hussain S, Singh A, Akhtar M, Najmi A . Vitamin D supplementation for the management of knee osteoarthritis: a systematic review of randomized controlled trials. Rheumatol Int. 2017; 37(9):1489-1498. DOI: 10.1007/s00296-017-3719-0. View

Laslett L, Quinn S, Burgess J, Parameswaran V, Winzenberg T, Jones G . Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2013; 73(4):697-703. DOI: 10.1136/annrheumdis-2012-202831. View

Vaishya R, Vijay V, Lama P, Agarwal A . Does vitamin D deficiency influence the incidence and progression of knee osteoarthritis? - A literature review. J Clin Orthop Trauma. 2019; 10(1):9-15. PMC: 6349580. DOI: 10.1016/j.jcot.2018.05.012. View

Das S, Farooqi A . Osteoarthritis. Best Pract Res Clin Rheumatol. 2008; 22(4):657-75. DOI: 10.1016/j.berh.2008.07.002. View

Bischoff-Ferrari H, Zhang Y, Kiel D, Felson D . Positive association between serum 25-hydroxyvitamin D level and bone density in osteoarthritis. Arthritis Rheum. 2005; 53(6):821-6. DOI: 10.1002/art.21601. View

Arden N, Cro S, Sheard S, Dore C, Bara A, Tebbs S . The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial. Osteoarthritis Cartilage. 2016; 24(11):1858-1866. PMC: 5045720. DOI: 10.1016/j.joca.2016.05.020. View

10.

Heidari B, Heidari P, Hajian-Tilaki K . Association between serum vitamin D deficiency and knee osteoarthritis. Int Orthop. 2010; 35(11):1627-31. PMC: 3193973. DOI: 10.1007/s00264-010-1186-2. View

11.

Ackerman I, Bucknill A, Page R, Broughton N, Roberts C, Cavka B . The substantial personal burden experienced by younger people with hip or knee osteoarthritis. Osteoarthritis Cartilage. 2015; 23(8):1276-84. DOI: 10.1016/j.joca.2015.04.008. View

12.

Unsal Malas F, Kara M, Aktekin L, Ersoz M, Ozcakar L . Does vitamin D affect femoral cartilage thickness? An ultrasonographic study. Clin Rheumatol. 2013; 33(9):1331-4. DOI: 10.1007/s10067-013-2432-y. View

13.

Zhang F, Driban J, Lo G, Price L, Booth S, Eaton C . Vitamin D deficiency is associated with progression of knee osteoarthritis. J Nutr. 2014; 144(12):2002-8. PMC: 4230211. DOI: 10.3945/jn.114.193227. View

14.

Sanghi D, Mishra A, Sharma A, Singh A, Natu S, Agarwal S . Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013; 471(11):3556-62. PMC: 3792285. DOI: 10.1007/s11999-013-3201-6. View

15.

McAlindon T, Felson D, Zhang Y, Hannan M, Aliabadi P, Weissman B . Relation of dietary intake and serum levels of vitamin D to progression of osteoarthritis of the knee among participants in the Framingham Study. Ann Intern Med. 1996; 125(5):353-9. DOI: 10.7326/0003-4819-125-5-199609010-00001. View

16.

McAlindon T, LaValley M, Schneider E, Nuite M, Lee J, Price L . Effect of vitamin D supplementation on progression of knee pain and cartilage volume loss in patients with symptomatic osteoarthritis: a randomized controlled trial. JAMA. 2013; 309(2):155-62. PMC: 3984919. DOI: 10.1001/jama.2012.164487. View

17.

Felson D, Niu J, Clancy M, Aliabadi P, Sack B, Guermazi A . Low levels of vitamin D and worsening of knee osteoarthritis: results of two longitudinal studies. Arthritis Rheum. 2006; 56(1):129-36. DOI: 10.1002/art.22292. View

18.

Roos E, Roos H, Lohmander L, Ekdahl C, Beynnon B . Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998; 28(2):88-96. DOI: 10.2519/jospt.1998.28.2.88. View

19.

Wieland H, Michaelis M, Kirschbaum B, Rudolphi K . Osteoarthritis - an untreatable disease?. Nat Rev Drug Discov. 2005; 4(4):331-44. DOI: 10.1038/nrd1693. View

20.

Al-Jarallah K, Shehab D, Al-Awadhi A, Nahar I, Haider M, Moussa M . Are 25(OH)D levels related to the severity of knee osteoarthritis and function?. Med Princ Pract. 2011; 21(1):74-8. DOI: 10.1159/000330025. View