Maternal Immunological Adaptation During Normal Pregnancy

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2020 Nov 2

PMID 33133091

Citations 214

Authors

Bahaa Abu-Raya

Christina Michalski

Manish Sadarangani

Pascal M Lavoie

Affiliations

Soon will be listed here.

Abstract

The risk and severity of specific infections are increased during pregnancy due to a combination of physiological and immunological changes. Characterizing the maternal immune system during pregnancy is important to understand how the maternal immune system maintains tolerance towards the allogeneic fetus. This may also inform strategies to prevent maternal fatalities due to infections and optimize maternal vaccination to best protect the mother-fetus dyad and the infant after birth. In this review, we describe what is known about the immunological changes that occur during a normal pregnancy.

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