The Unfolded Protein Response and Autophagy As Drug Targets in Neuropsychiatric Disorders

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2020 Nov 2

PMID 33132844

Citations 7

Authors

Vignesh Srinivasan

Laura Korhonen

Dan Lindholm

Affiliations

Soon will be listed here.

Abstract

Neurons are polarized in structure with a cytoplasmic compartment extending into dendrites and a long axon that terminates at the synapse. The high level of compartmentalization imposes specific challenges for protein quality control in neurons making them vulnerable to disturbances that may lead to neurological dysfunctions including neuropsychiatric diseases. Synapse and dendrites undergo structural modulations regulated by neuronal activity involve key proteins requiring strict control of their turnover rates and degradation pathways. Recent advances in the study of the unfolded protein response (UPR) and autophagy processes have brought novel insights into the specific roles of these processes in neuronal physiology and synaptic signaling. In this review, we highlight recent data and concepts about UPR and autophagy in neuropsychiatric disorders and synaptic plasticity including a brief outline of possible therapeutic approaches to influence UPR and autophagy signaling in these diseases.

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