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Leukocyte Populations and Their Cell Adhesion Molecules Expression in Newborn Dromedary Camel Calves

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Journal Vet World
Date 2020 Nov 2
PMID 33132598
Citations 5
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Abstract

Background And Aim: Different properties of the newborn immune system have been characterized in many species. For the newborn camel calf, however, the phenotype and composition of blood leukocytes have so far not been evaluated. The current study aimed to analyze the distribution of leukocyte subpopulations and their expression pattern of cell adhesion molecules in newborn and adult dromedary camels.

Materials And Methods: Blood samples were collected from 17 newborn camel calves and 32 adult camels. For each sample, total leukocytes were separated and analyzed for their composition and cell adhesion molecules expression by flow cytometry.

Results: In comparison to adult camels, newborn camel calves had higher leukocyte numbers and higher numbers of neutrophils, monocytes, and lymphocytes but lower numbers of eosinophils in their blood. Among the lymphocyte populations in calves, the fractions of B cells and γ T cells were elevated when compared to adults, whereas CD4-positive T cells were reduced. The comparison between camel calves and adult camels revealed significantly lower expression of the cell adhesion molecules CD11a, CD11b, and CD18 on granulocytes, monocytes, and lymphocytes in calves.

Conclusion: Newborn camel calves show a distinct composition and phenotype pattern of blood leukocytes when compared to adult camels. The observed rise in many leukocyte populations in calf blood may be due to reduced migratory activity in calf leukocyte populations.

Citing Articles

Haematological and biochemical blood reference values for Canary Island camels (), an endangered dromedary species.

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PMID: 37213697 PMC: 10196958. DOI: 10.1016/j.sjbs.2023.103677.


Blood Gas, Acid-Base and Electrolyte Analysis in Healthy Dromedary Camel Calves up to 21 Days of Life.

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The Impact of the Animal Housing System on Immune Cell Composition and Function in the Blood of Dromedary Camels.

Hussen J, Al-Sukruwah M Animals (Basel). 2022; 12(3).

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Recent Advances in Camel Immunology.

Hussen J, Schuberth H Front Immunol. 2021; 11:614150.

PMID: 33569060 PMC: 7868527. DOI: 10.3389/fimmu.2020.614150.

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