Sex Specific Expression of Interleukin 7, 8 and 15 in Placentas of Women with Gestational Diabetes

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2020 Oct 31

PMID 33126577

Citations 11

Authors

Simon Keckstein

Sophia Pritz

Niklas Amann

Sarah Meister

Susanne Beyer

Magdalena Jegen

Christina Kuhn

Stefan Hutter

Julia Knabl

Sven Mahner

Thomas Kolben

Udo Jeschke

Theresa M Kolben

Affiliations

Soon will be listed here.

Abstract

Gestational diabetes mellitus (GDM) is known to increase the risk for feto-maternal complications during pregnancy. A state of low-grade inflammation, with elevated levels of proinflammatory molecules, similar to patients with obesity or diabetes mellitus type 2 has also been partly described in GDM. The placenta, as unique interface between mother and fetus, is not only passively affected by changes in one of these organisms, but also acts as a modulator by expressing hormones and cytokines. This study aimed to investigate the expression of the proinflammatory cytokines Interleukin (IL) 7, 8 and 15 in GDM in placental tissue. A total number of 80 placentas were included (40 GDM/40 control group). The expression of IL-7, 8 and 15 was investigated in extravillous trophoblast (EVT) and syncytiotrophoblast (SCT) by immunohistochemistry and immunofluorescence double staining. The immunohistochemical staining was evaluated with the semiquanitfied immunoreactive score (IRS). While the expression IL-15 was significantly upregulated in EVTs of women with GDM. The expression of IL-8 was significantly decreased in EVT of the GDM group. Furthermore, significant fetal sex specific differences were detectable in all three cytokines. Our findings suggest an involvement of the investigated cytokines in the maintenance of a state of chronic low-grade inflammation on placental level in patients suffering from GDM.

Citing Articles

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Galectin-10 Expression in Placentas of Women with Gestational Diabetes.

Buschmann C, Unverdorben L, Knabl J, Hutter S, Meister S, Beyer S Curr Issues Mol Biol. 2023; 45(11):8840-8851.

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