MicroRNA-24 in Cancer: A Double Side Medal With Opposite Properties

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Oct 30

PMID 33123467

Citations 15

Authors

Sumei Wang

Nayan Liu

Qing Tang

Honghao Sheng

Shunqin Long

Wanyin Wu

Affiliations

Soon will be listed here.

Abstract

MicroRNA-24 (miR-24) has been widely studied in a variety of human cancers, which plays different roles in specific type of cancers. In the present review, we summarized the recent surveys regarding the role of miR-24 in different human cancers. On the one hand, miR-24 was reported to be down-regulated in some types of cancer, indicating its role as a tumor suppressor. On the other hand, it has shown that miR-24 was up-regulated in some other types of cancer, even in the same type of cancer, suggesting the role of miR-24 being as an oncogene. Firstly, miR-24 was dysregualted in human cancers, which is related to the clinical performance of cancer patients. Thus miR-24 could be used as a potential non-invasive diagnostic marker in human cancers. Secondly, miR-24 was associated with the tumor initiation and progression, being as a promoter or inhibitor. Therefore, miR-24 might be an effective prognostic biomarker in different type of cancers. Lastly, the abnormal expression of miR-24 was involved in the chemo- and radio- therapies of cancer patients, indicating the role of miR-24 being as a predictive biomarker to cancer treatment. Totally, miR-24 contributes to tumorigenesis, tumor progression, and tumor therapy, which closely related to clinic. The present review shows that miR-24 plays a double role in human cancers and provides plenty of evidences to apply miR-24 as a potential novel therapeutic target in treating human cancers.

Citing Articles

Keratinocyte-derived extracellular vesicles in painful diabetic neuropathy.

Coy-Dibley J, Jayaraj N, Ren D, Pacifico P, Belmadani A, Wang Y Neurobiol Pain. 2025; 17:100176.

PMID: 39811188 PMC: 11731614. DOI: 10.1016/j.ynpai.2024.100176.

Plasma microRNAs as Biomarkers for Predicting Radiotherapy Treatment-Induced Cardiotoxicity in Lung Cancer.

Kazlauskaite P, Vaicekauskaite I, Venius J, Sabaliauskaite R, Steponaviciene R Life (Basel). 2025; 14(12.

PMID: 39768327 PMC: 11679788. DOI: 10.3390/life14121619.

Protective effects of miR-24-2-5p in early stages of breast cancer bone metastasis.

Puppo M, Croset M, Ceresa D, Valluru M, Canuas Landero V, Hernandez Guadarrama M Breast Cancer Res. 2024; 26(1):186.

PMID: 39696397 PMC: 11656574. DOI: 10.1186/s13058-024-01934-2.

MicroRNA‑24 alleviates colorectal cancer progression via a rs28382740 single nucleotide polymorphism in the long noncoding region of X‑linked inhibitor of apoptosis protein.

Tian Y, Huang C, Liu C, Yang S, Hung C, Lin K Oncol Lett. 2024; 28(6):591.

PMID: 39417038 PMC: 11481099. DOI: 10.3892/ol.2024.14724.

Expression Analysis of Circulating microRNAs in Saliva and Plasma for the Identification of Clinically Relevant Biomarkers for Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders.

Rocchetti F, Tenore G, Macali F, Vicidomini T, Podda G, Fantozzi P Cancers (Basel). 2024; 16(17).

PMID: 39272848 PMC: 11394426. DOI: 10.3390/cancers16172990.

References

Oliveto S, Alfieri R, Miluzio A, Scagliola A, Secli R, Gasparini P . A Polysome-Based microRNA Screen Identifies miR-24-3p as a Novel Promigratory miRNA in Mesothelioma. Cancer Res. 2018; 78(20):5741-5753. PMC: 6193539. DOI: 10.1158/0008-5472.CAN-18-0655. View

Li X, Han X, Wei P, Yang J, Sun J . Knockdown of lncRNA CCAT1 enhances sensitivity of paclitaxel in prostate cancer via regulating miR-24-3p and FSCN1. Cancer Biol Ther. 2020; 21(5):452-462. PMC: 7515504. DOI: 10.1080/15384047.2020.1727700. View

Rashed W, Hammad A, Saad A, Shohdy K . MicroRNA as a diagnostic biomarker in childhood acute lymphoblastic leukemia; systematic review, meta-analysis and recommendations. Crit Rev Oncol Hematol. 2019; 136:70-78. DOI: 10.1016/j.critrevonc.2019.02.008. View

Yan L, Ma J, Zhu Y, Zan J, Wang Z, Ling L . miR-24-3p promotes cell migration and proliferation in lung cancer by targeting SOX7. J Cell Biochem. 2017; 119(5):3989-3998. DOI: 10.1002/jcb.26553. View

Wong C, Tsang F, Ng I . Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications. Nat Rev Gastroenterol Hepatol. 2018; 15(3):137-151. DOI: 10.1038/nrgastro.2017.169. View

Zhang Q, Li W, Liu G, Tang W . MicroRNA-24 regulates the growth and chemosensitivity of the human colorectal cancer cells by targeting RNA-binding protein DND1. J BUON. 2019; 24(4):1476-1481. View

Olbromski M, Rzechonek A, Grzegrzolka J, Glatzel-Plucinska N, Chachaj A, Werynska B . Influence of miR-7a and miR-24-3p on the SOX18 transcript in lung adenocarcinoma. Oncol Rep. 2017; 39(1):201-208. DOI: 10.3892/or.2017.6077. View

Acunzo M, Romano G, Wernicke D, Croce C . MicroRNA and cancer--a brief overview. Adv Biol Regul. 2014; 57:1-9. DOI: 10.1016/j.jbior.2014.09.013. View

Lu K, Wang J, Song Y, Zhao S, Liu H, Tang D . miRNA-24-3p promotes cell proliferation and inhibits apoptosis in human breast cancer by targeting p27Kip1. Oncol Rep. 2015; 34(2):995-1002. DOI: 10.3892/or.2015.4025. View

10.

Zhang S, Zhang C, Liu W, Zheng W, Zhang Y, Wang S . MicroRNA-24 upregulation inhibits proliferation, metastasis and induces apoptosis in bladder cancer cells by targeting CARMA3. Int J Oncol. 2015; 47(4):1351-60. DOI: 10.3892/ijo.2015.3117. View

11.

Listing H, Mardin W, Wohlfromm S, Mees S, Haier J . MiR-23a/-24-induced gene silencing results in mesothelial cell integration of pancreatic cancer. Br J Cancer. 2014; 112(1):131-9. PMC: 4453619. DOI: 10.1038/bjc.2014.587. View

12.

Grimaldi A, Zarone M, Irace C, Zappavigna S, Lombardi A, Kawasaki H . Non-coding RNAs as a new dawn in tumor diagnosis. Semin Cell Dev Biol. 2017; 78:37-50. DOI: 10.1016/j.semcdb.2017.07.035. View

13.

Yan Q, Chen T, Yang H, Yu H, Zheng Y, He T . The Effect of FERMT1 Regulated by miR-24 on the Growth and Radiation Resistance of Esophageal Cancer. J Biomed Nanotechnol. 2019; 15(3):621-631. DOI: 10.1166/jbn.2019.2711. View

14.

He L, Ping F, Fan Z, Zhang C, Deng M, Cheng B . Salivary exosomal miR-24-3p serves as a potential detective biomarker for oral squamous cell carcinoma screening. Biomed Pharmacother. 2019; 121:109553. DOI: 10.1016/j.biopha.2019.109553. View

15.

Shen Z, Hao W, Zhou C, Deng H, Ye D, Li Q . Long non-coding RNA AC026166.2-001 inhibits cell proliferation and migration in laryngeal squamous cell carcinoma by regulating the miR-24-3p/p27 axis. Sci Rep. 2018; 8(1):3375. PMC: 5820272. DOI: 10.1038/s41598-018-21659-5. View

16.

Liu Z, Jiang L, Zhang G, Li S, Jiang X . MiR-24 promotes migration and invasion of non-small cell lung cancer by targeting ZNF367. J BUON. 2018; 23(5):1413-1419. View

17.

Liu J, Chen Z, Cui Y, Wei H, Zhu Z, Mao F . Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia. Aging (Albany NY). 2020; 12(4):3298-3311. PMC: 7066883. DOI: 10.18632/aging.102813. View

18.

Duan Y, Hu L, Liu B, Yu B, Li J, Yan M . Tumor suppressor miR-24 restrains gastric cancer progression by downregulating RegIV. Mol Cancer. 2014; 13:127. PMC: 4041902. DOI: 10.1186/1476-4598-13-127. View

19.

Li Y, Lu J, Bao X, Wang X, Wu J, Hong W . MiR-24 functions as a tumor suppressor in nasopharyngeal carcinoma through targeting FSCN1. J Exp Clin Cancer Res. 2015; 34:130. PMC: 4621856. DOI: 10.1186/s13046-015-0242-6. View

20.

Wang S, Pan Y, Xu T, Wu W, Zhang R, Wang C . Hsa-miR-24-3p increases nasopharyngeal carcinoma radiosensitivity by targeting both the 3'UTR and 5'UTR of Jab1/CSN5. Oncogene. 2016; 35(47):6096-6108. PMC: 5102828. DOI: 10.1038/onc.2016.147. View