Vitamin D (1,25-(OH)D) Improves Endothelial Progenitor Cells Function Via Enhanced NO Secretion in Systemic Lupus Erythematosus

Overview

Journal Cardiol Res Pract

Publisher Wiley

Specialty Cardiology & Vascular Diseases

Date 2020 Oct 30

PMID 33123377

Citations 6

Authors

Zhenhua Huang

Lixiang Liu

Shufen Huang

Jianbo Li

Shaozhen Feng

Naya Huang

Zhen Ai

Weiqing Long

Lanping Jiang

Affiliations

Soon will be listed here.

Abstract

It has been proven that vitamin D was decreased and function of circulating endothelial progenitor cells (EPCs) was injured in systemic lupus erythematosus (SLE) patients. However, the effect of vitamin D on the function of EPCs and its mechanism need further study. Therefore, we investigated whether vitamin D improved the function of EPCs . The peripheral blood mononuclear cells of the participants were isolated from SLE patients and control subjects and cultured to EPCs. After the EPCs were treated with vitamin D (1,25-(OH)D), we evaluated the number, migratory and proliferative activities, and nitric oxide (NO) production of EPCs and detected vascular endothelial function by flow-mediated dilatation (FMD). We found that vitamin D in a dose-dependent manner improved number and migratory and proliferative activities of EPCs from SLE patients. Additionally, vitamin D upregulated NO production from EPCs . A significant correlation between the FMD and plasma NO level was found. There was also a correlation between number, migration, and proliferation of EPCs and NO production. Thus, the present findings indicated that vitamin D improved the function of EPCs from SLE patients via NO secretion.

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