Assessment of the Relationship Between Clinical Variants of Psoriasis and () Genes: A Systematic Review with Meta-analysis

Background: Psoriasis (Ps) is an autoimmune dermatosis. Previous studies have shown an association between genes and susceptibility to some clinical variants of Ps. Therefore, we conducted an exhaustive systematic review with meta-analysis to evaluate the relationship between genes and susceptibility to clinical variants of Ps in the overall population and according to ethnicity.

Methods: According to PRISMA guidelines, we performed a systematic review through PubMed and Web of Science to identify relevant available scientific publications about genes and Ps. The quality of the studies was evaluated using the Newcastle-Ottawa scale. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using random and fixed effect models for the analyzed genes. Heterogeneity was tested using Cochran's -Statistic and I, and the risk of bias was tested using the Begg test and Egger linear regression.

Results: A total of 10 case-control studies were included, comprising a variable number of typified genes and psoriasis vulgaris (PsV) as the main clinical variant studied. In the total pooled results, the gene (OR = 1.518, = .010, 95%CI: 1.105 to 2.086) was related to higher susceptibility to PsV, while the (OR = 0.563, = .005, 95%CI: 0.376 to 0.842) and (OR = 0.602, = .040, 95%CI: 0.370 to 0.977) genes were related to protection against PsV.

Conclusion: This meta-analysis demonstrates that subjects that carry the gene could have a potential risk factor for the development of PsV. Conversely, and genes appear to confer protection against PsV.