Craniofacial Morphology of HIV-infected Adolescents Undergoing Highly Active Antiretroviral Therapy (HAART): An Original Research

Overview

Journal J Orthod Sci

Date 2020 Oct 28

PMID 33110767

Citations 1

Authors

M Neeraja

Anand Garabadu

Subash Chandra Nayak

Monalisa Das

Debashish Dash

Anurag Tiwari

Abhishek Singh Nayyar

Affiliations

Soon will be listed here.

Abstract

Objectives: To analyze the craniofacial morphology in child patients and adolescents by evaluating the skeletal cephalometric profile of the HIV infected patients in this age group and comparing them with the HIV-negative controls.

Materials And Methods: The present study was a planned case-control study which included 25 HIV-positive adolescent patients aged between 10 and 18 years (the study group) who were compared with 25 age- and sex-matched HIV-negative adolescent controls (the control group). All the patients had been HIV infected via a vertical transmission with positive serology confirmed in two different tests and had been kept on HAART since they were born. The diagnostic aids used for orthodontic documentation included facial photographs, digital orthopantomographs, lateral teleradiographs, and study models.

Results: With reference to the methodologies used for taking the cephalometric values, all the methods used were in strong agreement with each other for almost all the variables studied and had high intra-class correlation coefficient values except Co-A, SN.ANSPNS, and SNB which, too, had a good agreement of 60%. Nevertheless, the agreement was positive for these variables, too, since the values obtained were found to be statistically significant ( < 0.05).

Conclusion: Most of the measurements in the HIV-infected adolescents were found to be similar to the ones obtained for the HIV-negative controls, although, the study results highlighted the significance of further studies to be conducted in this regard, especially, the longitudinal study designs wherein the said variables can be studied on a follow-up basis in longitudinal studies to have an idea of the exact changes observed and their pattern in the included groups.

Citing Articles

Evaluation of the mandibular condylar bone microarchitecture in people living with HIV.

Wadhwa S, Levit M, Matsumura S, Hsieh S, Kister K, Silva C Oral Dis. 2023; 30(4):2355-2361.

PMID: 37338087 PMC: 10730762. DOI: 10.1111/odi.14651.

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