PIWI-interacting RNAs and PIWI Proteins in Glioma: Molecular Pathogenesis and Role As Biomarkers

Overview

Journal Cell Commun Signal

Publisher Biomed Central

Specialties Biochemistry
Cell Biology

Date 2020 Oct 28

PMID 33109195

Citations 11

Authors

Omid Reza Tamtaji

Mohammad Behnam

Mohammad Ali Pourattar

Michael R Hamblin

Maryam Mahjoubin-Tehran

Hamed Mirzaei

Zatollah Asemi

Affiliations

Soon will be listed here.

Abstract

Glioma is the most common primary brain tumor, and is a major health problem throughout the world. Today, researchers have discovered many risk factors that are associated with the initiation and progression of gliomas. Studies have shown that PIWI-interacting RNAs (piRNAs) and PIWI proteins are involved in tumorigenesis by epigenetic mechanisms. Hence, it seems that piRNAs and PIWI proteins may be potential prognostic, diagnostic or therapeutic biomarkers in the treatment of glioma. Previous studies have demonstrated a relationship between piRNAs and PIWI proteins and some of the molecular and cellular pathways in glioma. Here, we summarize recent evidence and evaluate the molecular mechanisms by which piRNAs and PIWI proteins are involved in glioma. Video abstract.

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References

Leng X, Ma J, Liu Y, Shen S, Yu H, Zheng J . Mechanism of piR-DQ590027/MIR17HG regulating the permeability of glioma conditioned normal BBB. J Exp Clin Cancer Res. 2018; 37(1):246. PMC: 6180493. DOI: 10.1186/s13046-018-0886-0. View

Zhang L, Liang X, Li Y . Long non-coding RNA MEG3 inhibits cell growth of gliomas by targeting miR-93 and inactivating PI3K/AKT pathway. Oncol Rep. 2017; 38(4):2408-2416. DOI: 10.3892/or.2017.5871. View

Bahn J, Zhang Q, Li F, Chan T, Lin X, Kim Y . The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. Clin Chem. 2014; 61(1):221-30. PMC: 4332885. DOI: 10.1373/clinchem.2014.230433. View

Ross R, Weiner M, Lin H . PIWI proteins and PIWI-interacting RNAs in the soma. Nature. 2014; 505(7483):353-359. PMC: 4265809. DOI: 10.1038/nature12987. View

Zhao S, Deng Y, Liu Y, Chen X, Yang G, Mu Y . MicroRNA-153 is tumor suppressive in glioblastoma stem cells. Mol Biol Rep. 2013; 40(4):2789-98. DOI: 10.1007/s11033-012-2278-4. View

Zhang Y, Liu W, Li R, Gu J, Wu P, Peng C . Structural insights into the sequence-specific recognition of Piwi by Papi. Proc Natl Acad Sci U S A. 2018; 115(13):3374-3379. PMC: 5879672. DOI: 10.1073/pnas.1717116115. View

Shirayama M, Seth M, Lee H, Gu W, Ishidate T, Conte Jr D . piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell. 2012; 150(1):65-77. PMC: 3597741. DOI: 10.1016/j.cell.2012.06.015. View

Shen S, Yu H, Liu X, Liu Y, Zheng J, Wang P . PIWIL1/piRNA-DQ593109 Regulates the Permeability of the Blood-Tumor Barrier via the MEG3/miR-330-5p/RUNX3 Axis. Mol Ther Nucleic Acids. 2018; 10:412-425. PMC: 5862138. DOI: 10.1016/j.omtn.2017.12.020. View

Mei P, Bai J, Liu H, Li C, Wu Y, Yu Z . RUNX3 expression is lost in glioma and its restoration causes drastic suppression of tumor invasion and migration. J Cancer Res Clin Oncol. 2011; 137(12):1823-30. DOI: 10.1007/s00432-011-1063-4. View

10.

Wank M, Schilling D, Schmid T, Meyer B, Gempt J, Barz M . Human Glioma Migration and Infiltration Properties as a Target for Personalized Radiation Medicine. Cancers (Basel). 2018; 10(11). PMC: 6266328. DOI: 10.3390/cancers10110456. View

11.

Mani S, Juliano C . Untangling the web: the diverse functions of the PIWI/piRNA pathway. Mol Reprod Dev. 2013; 80(8):632-64. PMC: 4234069. DOI: 10.1002/mrd.22195. View

12.

Guo B, Li D, Du L, Zhu X . piRNAs: biogenesis and their potential roles in cancer. Cancer Metastasis Rev. 2020; 39(2):567-575. DOI: 10.1007/s10555-020-09863-0. View

13.

Janic A, Mendizabal L, Llamazares S, Rossell D, Gonzalez C . Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science. 2011; 330(6012):1824-7. DOI: 10.1126/science.1195481. View

14.

Ellis B, Molloy P, Graham L . CRNDE: A Long Non-Coding RNA Involved in CanceR, Neurobiology, and DEvelopment. Front Genet. 2012; 3:270. PMC: 3509318. DOI: 10.3389/fgene.2012.00270. View

15.

Wang Y, Wang Y, Li J, Zhang Y, Yin H, Han B . CRNDE, a long-noncoding RNA, promotes glioma cell growth and invasion through mTOR signaling. Cancer Lett. 2015; 367(2):122-8. DOI: 10.1016/j.canlet.2015.03.027. View

16.

Krishnan P, Damaraju S . The Challenges and Opportunities in the Clinical Application of Noncoding RNAs: The Road Map for miRNAs and piRNAs in Cancer Diagnostics and Prognostics. Int J Genomics. 2018; 2018:5848046. PMC: 5952559. DOI: 10.1155/2018/5848046. View

17.

Sun W, Samimi H, Gamez M, Zare H, Frost B . Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies. Nat Neurosci. 2018; 21(8):1038-1048. PMC: 6095477. DOI: 10.1038/s41593-018-0194-1. View

18.

Shan N, Shen L, Wang J, He D, Duan C . MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19. Biochem Biophys Res Commun. 2014; 456(1):385-91. DOI: 10.1016/j.bbrc.2014.11.093. View

19.

Keam S, Young P, McCorkindale A, Dang T, Clancy J, Humphreys D . The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells. Nucleic Acids Res. 2014; 42(14):8984-95. PMC: 4132735. DOI: 10.1093/nar/gku620. View

20.

Shiraha H, Nishina S, Yamamoto K . Loss of runt-related transcription factor 3 causes development and progression of hepatocellular carcinoma. J Cell Biochem. 2011; 112(3):745-9. DOI: 10.1002/jcb.22973. View