Genetically Modified Mouse Models to Help Fight COVID-19

Overview

Journal Nat Protoc

Specialties Biology
Pathology
Science

Date 2020 Oct 27

PMID 33106680

Citations 21

Authors

Channabasavaiah B Gurumurthy

Rolen M Quadros

Guy P Richardson

Larisa Y Poluektova

Suzanne L Mansour

Masato Ohtsuka

Affiliations

Soon will be listed here.

Abstract

The research community is in a race to understand the molecular mechanisms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, to repurpose currently available antiviral drugs and to develop new therapies and vaccines against coronavirus disease 2019 (COVID-19). One major challenge in achieving these goals is the paucity of suitable preclinical animal models. Mice constitute ~70% of all the laboratory animal species used in biomedical research. Unfortunately, SARS-CoV-2 infects mice only if they have been genetically modified to express human ACE2. The inherent resistance of wild-type mice to SARS-CoV-2, combined with a wealth of genetic tools that are available only for modifying mice, offers a unique opportunity to create a versatile set of genetically engineered mouse models useful for COVID-19 research. We propose three broad categories of these models and more than two dozen designs that may be useful for SARS-CoV-2 research and for fighting COVID-19.

Citing Articles

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Neuromuscular defects after infection with a beta coronavirus in mice.

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Ethical considerations regarding animal experimentation.

Kiani A, Pheby D, Henehan G, Brown R, Sieving P, Sykora P J Prev Med Hyg. 2022; 63(2 Suppl 3):E255-E266.

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Cell and Animal Models for SARS-CoV-2 Research.

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