Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem

Overview

Journal iScience

Publisher Cell Press

Date 2020 Oct 26

PMID 33103073

Citations 9

Authors

David Pamies

Marie-Gabrielle Zurich

Thomas Hartung

Affiliations

Soon will be listed here.

Abstract

Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient models used to study the disease. Advances in stem cell and cultures technologies are promising, however, and here we present the advantages and limitations of available organotypic culture models and discuss their possible applications for studying glioblastoma.

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