Advanced Hydrogels for the Repair of Cartilage Defects and Regeneration

Overview

Journal Bioact Mater

Specialty Biomedical Engineering

Date 2020 Oct 26

PMID 33102942

Citations 109

Authors

Wei Wei

Yuanzhu Ma

Xudong Yao

Wenyan Zhou

Xiaozhao Wang

Chenglin Li

Junxin Lin

Qiulin He

Sebastian Leptihn

Hongwei Ouyang

Affiliations

Soon will be listed here.

Abstract

Cartilage defects are one of the most common symptoms of osteoarthritis (OA), a degenerative disease that affects millions of people world-wide and places a significant socio-economic burden on society. Hydrogels, which are a class of biomaterials that are elastic, and display smooth surfaces while exhibiting high water content, are promising candidates for cartilage regeneration. In recent years, various kinds of hydrogels have been developed and applied for the repair of cartilage defects or , some of which are hopeful to enter clinical trials. In this review, recent research findings and developments of hydrogels for cartilage defects repair are summarized. We discuss the principle of cartilage regeneration, and outline the requirements that have to be fulfilled for the deployment of hydrogels for medical applications. We also highlight the development of advanced hydrogels with tailored properties for different kinds of cartilage defects to meet the requirements of cartilage tissue engineering and precision medicine.

Citing Articles

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